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Accuracy of two circulating antigen tests for the diagnosis and surveillance of; Schistosoma mansoni; infection in low-endemicity settings of Côte d'Ivoire
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4646535
Author(s) Assaré, R. K.; Tra-Bi, M. I.; Coulibaly, J. T.; Corstjens, P. L. A. M.; Ouattara, M.; Hürlimann, E.; van Dam, G. J.; Utzinger, J.; N'Goran, E. K.
Author(s) at UniBasel Kouassi Rufin, Assare
Coulibaly, Jean
Hürlimann, Eveline
Utzinger, Jürg
Year 2021
Title Accuracy of two circulating antigen tests for the diagnosis and surveillance of; Schistosoma mansoni; infection in low-endemicity settings of Côte d'Ivoire
Journal The American journal of tropical medicine and hygiene
Volume 105
Number 3
Pages / Article-Number 677-683
Mesh terms Animals; Antigens, Helminth, urine; Child; Cote d'Ivoire; Feces, parasitology; Female; Glycoproteins, urine; Helminth Proteins, urine; Humans; Male; Schistosoma mansoni, immunology; Schistosomiasis mansoni, urine; Sensitivity and Specificity; Seroepidemiologic Studies; Serologic Tests; Urine, parasitology
Abstract In low-endemicity settings, current tools for the diagnosis and surveillance of schistosomiasis are often inaccurate in detecting true infection. We assessed the accuracy of an up-converting phosphor lateral flow circulating anodic antigen (UCP-LF CAA) test and a point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for the diagnosis of Schistosoma mansoni. Our study was conducted in eight schools of western Côte d'Ivoire. Fifty children, aged 9-12 years, were enrolled per school. From each child, a single urine specimen and two stool specimens were collected over consecutive days for diagnostic work-up. Urine samples were subjected to UCP-LF CAA and POC-CCA tests. From each stool sample, triplicate Kato-Katz thick smears were examined. Overall, 378 children had complete data records. The prevalence of S. mansoni, as assessed by six Kato-Katz thick smears, was 4.0%. The UCP-LF CAA and POC-CCA tests revealed S. mansoni prevalence of 25.4% and 30.7%, respectively, when considering trace results as positive, and prevalence of 23.3% and 10.9% when considering trace results as negative. In the latter case, based on a composite "gold" standard, the sensitivity of UCP-LF CAA (80.7%) was considerably higher than that of POC-CCA (37.6%) and six Kato-Katz thick smears (13.8%). The negative predictive value of UCP-LF CAA, POC-CCA, and six Kato-Katz thick smears was 92.8%, 79.8%, and 74.1%, respectively. Our results confirm that UCP-LF CAA is more accurate than Kato-Katz and POC-CCA for the diagnosis of S. mansoni in low-endemicity settings.
ISSN/ISBN 0002-9637
edoc-URL https://edoc.unibas.ch/88899/
Full Text on edoc No
Digital Object Identifier DOI 10.4269/ajtmh.21-0031
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34280143
ISI-Number WOS:000701988100025
Document type (ISI) Journal Article
 
   

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