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Anthelmintic activity and cytotoxic effects of compounds isolated from the fruits of Ozoroa insignis del. (Anacardiaceae)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4646435
Author(s) Dube, M.; Saoud, M.; Rennert, R.; Fotso, G. W.; Andrae-Marobela, K.; Imming, P.; Häberli, C.; Keiser, J.; Arnold, N.
Author(s) at UniBasel Häberli, Cécile
Keiser, Jennifer
Year 2021
Title Anthelmintic activity and cytotoxic effects of compounds isolated from the fruits of Ozoroa insignis del. (Anacardiaceae)
Journal Biomolecules
Volume 11
Number 12
Pages / Article-Number 1893
Keywords *Caenorhabditis elegans; *Ozoroa insignis Del.; *anthelmintic properties; *cytotoxicity; *fruits; *parasitic worms
Mesh terms Anacardiaceae, chemistry; Ancylostoma, growth & development; Animals; Anthelmintics, pharmacology; Antineoplastic Agents, Phytogenic, pharmacology; Caenorhabditis elegans, growth & development; Cell Proliferation, drug effects; Cell Survival, drug effects; Fruit, chemistry; HT29 Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Necator americanus, growth & development; Nematospiroides dubius, growth & development; PC-3 Cells; Plant Extracts, pharmacology; Schistosoma mansoni, growth & development; Strongyloides ratti, growth & development
Abstract Ozoroa insignis Del. is an ethnobotanical plant widely used in traditional medicine for various ailments, including schistosomiasis, tapeworm, and hookworm infections. From the so far not investigated fruits of Ozoroa insignis, the anthelmintic principles could be isolated through bioassay-guided isolation using Caenorhabditis elegans and identified by NMR spectroscopic analysis and mass spectrometric studies. Isolated 6-[8(Z)-pentadecenyl] anacardic (1), 6-[10(Z)-heptadecenyl] anacardic acid (2), and 3-[7(Z)-pentadecenyl] phenol (3) were evaluated against the 5 parasitic organisms Schistosoma mansoni (adult and newly transformed schistosomula), Strongyloides ratti, Heligmosomoides polygyrus, Necator americanus, and Ancylostoma ceylanicum, which mainly infect humans and other mammals. Compounds 1-3 showed good activity against Schistosoma mansoni, with compound 1 showing the best activity against newly transformed schistosomula with 50% activity at 1microM. The isolated compounds were also evaluated for their cytotoxic properties against PC-3 (human prostate adenocarcinoma) and HT-29 (human colorectal adenocarcinoma) cell lines, whereby compounds 2 and 3 showed antiproliferative activity in both cancer cell lines, while compound 1 exhibited antiproliferative activity only on PC-3 cells. With an IC50 value of 43.2 microM, compound 3 was found to be the most active of the 3 investigated compounds.
ISSN/ISBN 2218-273X (Electronic)2218-273X (Linking)
URL https://doi.org/10.3390/biom11121893
edoc-URL https://edoc.unibas.ch/89038/
Full Text on edoc Available
Digital Object Identifier DOI 10.3390/biom11121893
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34944537
ISI-Number WOS:000736004300001
Document type (ISI) Journal Article
 
   

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28/03/2024