A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4643294
Author(s) Linkens, Armand Ma; Houben, Alfons Jhm; Niessen, Petra M; Wijckmans, Nicole Eg; de Goei, Erica Ec; Van den Eynde, Mathias Dg; Scheijen, Jean Ljm; van den Waarenburg, Marjo Ph; Mari, Andrea; Berendschot, Tos Tjm; Streese, Lukas; Hanssen, Henner; van Dongen, Martien Cjm; van Gool, Christel Cjaw; Stehouwer, Coen DA; Eussen, Simone Jmp; Schalkwijk, Casper G
Author(s) at UniBasel Streese, Lukas
Hanssen, Henner
Year 2022
Title A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals.
Journal JCI insight
Volume 7
Number 6
Pages / Article-Number 3
Keywords Clinical Trials; Glucose metabolism; Microcirculation; Vascular Biology
Mesh terms Diabetes Mellitus, Type 2; Diet; Glucose; Glycation End Products, Advanced; Humans; Inflammation; Insulin Resistance; Lipids; Lysine; Male; Obesity

BACKGROUNDAccumulation of advanced glycation endproducts (AGEs) may contribute to the pathophysiology of type 2 diabetes and its vascular complications. AGEs are widely present in food, but whether restricting AGE intake improves risk factors for type 2 diabetes and vascular dysfunction is controversial.METHODSAbdominally obese but otherwise healthy individuals were randomly assigned to a specifically designed 4-week diet low or high in AGEs in a double-blind, parallel design. Insulin sensitivity, secretion, and clearance were assessed by a combined hyperinsulinemic-euglycemic and hyperglycemic clamp. Micro- and macrovascular function, inflammation, and lipid profiles were assessed by state-of-the-art in vivo measurements and biomarkers. Specific urinary and plasma AGEs Nε-(carboxymethyl)lysine (CML), Nε-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were assessed by mass spectrometry.RESULTSIn 73 individuals (22 males, mean ± SD age and BMI 52 ± 14 years, 30.6 ± 4.0 kg/m2), intake of CML, CEL, and MG-H1 differed 2.7-, 5.3-, and 3.7-fold between the low- and high-AGE diets, leading to corresponding changes of these AGEs in urine and plasma. Despite this, there was no difference in insulin sensitivity, secretion, or clearance; micro- and macrovascular function; overall inflammation; or lipid profile between the low and high dietary AGE groups (for all treatment effects, P > 0.05).CONCLUSIONThis comprehensive RCT demonstrates very limited biological consequences of a 4-week diet low or high in AGEs in abdominally obese individuals.TRIAL REGISTRATIONClinicaltrials.gov, NCT03866343; trialregister.nl, NTR7594.FUNDINGDiabetesfonds and ZonMw.

ISSN/ISBN 2379-3708
Full Text on edoc
Digital Object Identifier DOI 10.1172/jci.insight.156950
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/35133989

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