Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4643294
Author(s) Linkens, Armand Ma; Houben, Alfons Jhm; Niessen, Petra M; Wijckmans, Nicole Eg; de Goei, Erica Ec; Van den Eynde, Mathias Dg; Scheijen, Jean Ljm; van den Waarenburg, Marjo Ph; Mari, Andrea; Berendschot, Tos Tjm; Streese, Lukas; Hanssen, Henner; van Dongen, Martien Cjm; van Gool, Christel Cjaw; Stehouwer, Coen DA; Eussen, Simone Jmp; Schalkwijk, Casper G
Author(s) at UniBasel Streese, Lukas
Hanssen, Henner
Year 2022
Title A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals.
Journal JCI insight
Volume 7
Number 6
Pages / Article-Number 3
Keywords Clinical Trials; Glucose metabolism; Microcirculation; Vascular Biology
Mesh terms Diabetes Mellitus, Type 2; Diet; Glucose; Glycation End Products, Advanced; Humans; Inflammation; Insulin Resistance; Lipids; Lysine; Male; Obesity

BACKGROUNDAccumulation of advanced glycation endproducts (AGEs) may contribute to the pathophysiology of type 2 diabetes and its vascular complications. AGEs are widely present in food, but whether restricting AGE intake improves risk factors for type 2 diabetes and vascular dysfunction is controversial.METHODSAbdominally obese but otherwise healthy individuals were randomly assigned to a specifically designed 4-week diet low or high in AGEs in a double-blind, parallel design. Insulin sensitivity, secretion, and clearance were assessed by a combined hyperinsulinemic-euglycemic and hyperglycemic clamp. Micro- and macrovascular function, inflammation, and lipid profiles were assessed by state-of-the-art in vivo measurements and biomarkers. Specific urinary and plasma AGEs Nε-(carboxymethyl)lysine (CML), Nε-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were assessed by mass spectrometry.RESULTSIn 73 individuals (22 males, mean ± SD age and BMI 52 ± 14 years, 30.6 ± 4.0 kg/m2), intake of CML, CEL, and MG-H1 differed 2.7-, 5.3-, and 3.7-fold between the low- and high-AGE diets, leading to corresponding changes of these AGEs in urine and plasma. Despite this, there was no difference in insulin sensitivity, secretion, or clearance; micro- and macrovascular function; overall inflammation; or lipid profile between the low and high dietary AGE groups (for all treatment effects, P > 0.05).CONCLUSIONThis comprehensive RCT demonstrates very limited biological consequences of a 4-week diet low or high in AGEs in abdominally obese individuals.TRIAL, NCT03866343;, NTR7594.FUNDINGDiabetesfonds and ZonMw.

ISSN/ISBN 2379-3708
Full Text on edoc
Digital Object Identifier DOI 10.1172/jci.insight.156950
PubMed ID

MCSS v5.8 PRO. 0.357 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |