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Brainstem Circuits Controlling Movement
Third-party funded project
Project title Brainstem Circuits Controlling Movement
Principal Investigator(s) Arber, Silvia
Project Members Kanodia, Harsh
Sridharan, Madhav
Organisation / Research unit Departement Biozentrum / Cell Biology (Arber),
Friedrich Miescher Institut FMI
Department Departement Biozentrum
Project Website https://data.snf.ch/grants/grant/208214
Project start 01.04.2022
Probable end 31.03.2026
Status Active
Abstract

One of the most important tasks of the nervous system is the generation of specific forms of movement as behavioral output, allowing animals or humans to interact with their surroundings appropriately according to motor plans and/or in response to influence from the environment. The motor system is broadly distributed across the nervous system, including areas close to actual motor program execution in the spinal cord, all the way up to regions of the nervous system involved in decision making and planning of motor acts. The brainstem is a key intermediary structure between higher motor centers and spinal circuits, and we have hypothesized that distinct subpopulations of brainstem neurons mediate selective motor programs. The goal of this work is to unravel key defining features of brainstem neurons involved in the regulation of diverse forms of movement, with an emphasis on understanding molecular and genetic underpinnings of brainstem neurons, as well as their plasticity during development and learning. Our project will contribute to uncovering organizational principles of neuronal circuits in the motor output system of mice, as well as the contributions of these circuits to behavioral function.

Financed by Swiss National Science Foundation (SNSF)
Follow-up project of 4439937 Brainstem Circuits Controlling Movement

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
4647577  Arber, Silvia; Costa, Rui M.  Networking brainstem and basal ganglia circuits for movement  1471-003X ; 1471-0048  Nature reviews. Neuroscience  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4647575  Krüttner, Sebastian; Falasconi, Antonio; Valbuena, Sergio; Galimberti, Ivan; Bouwmeester, Tewis; Arber, Silvia; Caroni, Pico  Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling  0896-6273 ; 1097-4199  Neuron  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4659084  Yang, Wuzhou; Kanodia, Harsh; Arber, Silvia  Structural and functional map for forelimb movement phases between cortex and medulla  0092-8674 ; 1097-4172  Cell  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4663167  Fidelin, Kevin; Arber, Silvia  Brainstem circuits help zebrafish get into the swim of things  0896-6273 ; 1097-4199  Neuron  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
   

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29/03/2024