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Brainstem Circuits Controlling Movement
Third-party funded project |
Project title |
Brainstem Circuits Controlling Movement |
Principal Investigator(s) |
Arber, Silvia
|
Project Members |
Kanodia, Harsh Sridharan, Madhav
|
Organisation / Research unit |
Departement Biozentrum / Cell Biology (Arber), Friedrich Miescher Institut FMI |
Department |
Departement Biozentrum |
Project Website |
https://data.snf.ch/grants/grant/208214 |
Project start |
01.04.2022 |
Probable end |
31.03.2026 |
Status |
Active |
Abstract |
One of the most important tasks of the nervous system is the generation of specific forms of movement as behavioral output, allowing animals or humans to interact with their surroundings appropriately according to motor plans and/or in response to influence from the environment. The motor system is broadly distributed across the nervous system, including areas close to actual motor program execution in the spinal cord, all the way up to regions of the nervous system involved in decision making and planning of motor acts. The brainstem is a key intermediary structure between higher motor centers and spinal circuits, and we have hypothesized that distinct subpopulations of brainstem neurons mediate selective motor programs. The goal of this work is to unravel key defining features of brainstem neurons involved in the regulation of diverse forms of movement, with an emphasis on understanding molecular and genetic underpinnings of brainstem neurons, as well as their plasticity during development and learning. Our project will contribute to uncovering organizational principles of neuronal circuits in the motor output system of mice, as well as the contributions of these circuits to behavioral function. |
Financed by |
Swiss National Science Foundation (SNSF)
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Follow-up project of |
4439937 Brainstem Circuits Controlling Movement
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Published results () |
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ID |
Autor(en) |
Titel |
ISSN / ISBN |
Erschienen in |
Art der Publikation |
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4647577 |
Arber, Silvia; Costa, Rui M. |
Networking brainstem and basal ganglia circuits for movement |
1471-003X ; 1471-0048 |
Nature reviews. Neuroscience |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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4647575 |
Krüttner, Sebastian; Falasconi, Antonio; Valbuena, Sergio; Galimberti, Ivan; Bouwmeester, Tewis; Arber, Silvia; Caroni, Pico |
Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling |
0896-6273 ; 1097-4199 |
Neuron |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
4659084 |
Yang, Wuzhou; Kanodia, Harsh; Arber, Silvia |
Structural and functional map for forelimb movement phases between cortex and medulla |
0092-8674 ; 1097-4172 |
Cell |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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4663167 |
Fidelin, Kevin; Arber, Silvia |
Brainstem circuits help zebrafish get into the swim of things |
0896-6273 ; 1097-4199 |
Neuron |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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29/03/2024
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