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Age at Time of Kidney Transplantation as a Predictor for Mortality, Graft Loss and Self-Rated Health Status: Results From the Swiss Transplant Cohort Study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4642222
Author(s) Beerli, Nadine; Denhaerynck, Kris; Binet, Isabelle; Dahdal, Suzan; Dickenmann, Michael; Golshayan, Delaviz; Hadaya, Karine; Huynh-Do, Uyen; Schnyder, Aurelia; De Geest, Sabina M.; Mauthner, Oliver
Author(s) at UniBasel Beerli, Nadine
Denhaerynck, Kris
De Geest, Sabina M.
Mauthner, Oliver
Year 2022
Title Age at Time of Kidney Transplantation as a Predictor for Mortality, Graft Loss and Self-Rated Health Status: Results From the Swiss Transplant Cohort Study
Journal Transplant International
Volume 35
Pages / Article-Number 10076
Keywords age; end stage renal disease; graft loss; mortality; patient reported outcome measures; renal transplantation
Mesh terms Adult; Aged; Cohort Studies; Graft Rejection, epidemiology; Graft Survival; Health Status; Humans; Kidney Transplantation; Middle Aged; Prospective Studies; Retrospective Studies; Risk Factors; Switzerland
Abstract Introduction:; The effect of age on health outcomes in kidney transplantation remains inconclusive. This study aimed to analyze the relationship between age at time of kidney transplantation with mortality, graft loss and self-rated health status in adult kidney transplant recipients.; Methods:; This study used data from the Swiss Transplant Cohort Study and included prospective data of kidney transplant recipients between 2008 and 2017. Time-to-event analysis was performed using Cox' regression analysis, and -in the case of graft loss- competing risk analysis. A random-intercept regression model was applied to analyse self-rated health status.; Results:; We included 2,366 kidney transplant recipients. Age at transplantation linearly predicted mortality. It was also predictive for graft loss, though nonlinearly, showing that recipients aged between 35 and 55 years presented with the lowest risk of experiencing graft loss. No relationship of age with self-rated health status was detected.; Conclusion:; Higher mortality in older recipients complies with data from the general population. The non-linear relationship between age and graft loss and the higher scored self-rated health status at all follow-up time-points compared to the pre-transplant status -regardless of age- highlight that age alone might not be an accurate measure for risk prediction and clinical decision making in kidney transplantation.
Publisher Frontiers
ISSN/ISBN 0934-0874 ; 1432-2277
edoc-URL https://edoc.unibas.ch/88015/
Full Text on edoc Available
Digital Object Identifier DOI 10.3389/ti.2021.10076
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/35185365
ISI-Number WOS:000753727800001
Document type (ISI) Journal Article
 
   

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