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RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4641843
Author(s) Millarte, Valentina; Spiess, Martin
Author(s) at UniBasel Spiess, Martin
Year 2022
Title RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis
Journal Autophagy
Volume 18
Pages / Article-Number 1-2
Keywords ATG16L1; FIP200; Rabaptin5; Salmonella; autophagy; early endosome
Abstract Selective autophagy of damaged organelles assures maintenance of cellular homeostasis in eukaryotes. While the mechanisms by which cells selectively remove dysfunctional mitochondria, lysosomes, endoplasmic reticulum and other organelles has been well characterized, little is known about specific autophagy of damaged early endosomes. In our recent study, we uncovered a new role for RABEP1/Rabaptin5, a long-established regulator of early endosome function, in targeting the autophagy machinery to early endosomes damaged by chloroquine or by internalized; Salmonella; via interaction with RB1CC1/FIP200 and ATG16L1.
Publisher Taylor & Francis
ISSN/ISBN 1554-8627 ; 1554-8635
edoc-URL https://edoc.unibas.ch/87905/
Full Text on edoc No
Digital Object Identifier DOI 10.1080/15548627.2021.2021497
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/35000547
Document type (ISI) Journal Article
 
   

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