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Incorporation of metal-chelating unnatural amino acids into halotag for allylic deamination
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4641374
Author(s) Stein, Alina; Liang, Alexandria Deliz; Sahin, Reyhan; Ward, Thomas R.
Author(s) at UniBasel Ward, Thomas R.
Year 2022
Title Incorporation of metal-chelating unnatural amino acids into halotag for allylic deamination
Journal Journal of Organometallic Chemistry
Volume 962
Pages / Article-Number 122272
Abstract The potential of artificial metalloenzymes has led to an increase in interest for the design of novel metal-binding sites in proteins. Metal-chelating unnatural amino acids offer an auspicious solution to engineer active metal sites in a defined way. Herein, we describe the introduction of four metal-chelating unnatural amino acids into HaloTag, an attractive scaffold for the assembly of functional artificial metalloenzymes. HaloTag, engineered with 2-amino-3-(8-hydroxyquinolin-5-yl)propanoic acid (HQ-Ala-1) was used to assemble an artificial metalloenzyme for improved allylic deamination upon complementation with [(η5-C5H5)Ru(MeCN)3]+.
Publisher Elsevier
ISSN/ISBN 0022-328X
edoc-URL https://edoc.unibas.ch/87795/
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/j.jorganchem.2022.122272
 
   

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