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Evaluation of the Expression of miR-486-3p, miR-548-3p, miR-561-5p and miR-509-5p in Tumor Biopsies of Patients with Oral Squamous Cell Carcinoma
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4641347
Author(s) Garajei, Ata; Parvin, Milad; Mohammadi, Hady; Allameh, Abdolamir; Hamidavi, Azin; Sadeghi, Masoud; Emami, Azadeh; Brand, Serge
Author(s) at UniBasel Brand, Serge
Year 2022
Title Evaluation of the Expression of miR-486-3p, miR-548-3p, miR-561-5p and miR-509-5p in Tumor Biopsies of Patients with Oral Squamous Cell Carcinoma
Journal Pathogens
Volume 11
Number 2
Pages / Article-Number 211
Abstract Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Expression patterns of microRNAs (miRNAs) can direct us in identifying valuable biomarkers for the prognosis of different neoplasms. Inappropriate regulation of miRNAs during physiological procedures can result in malignancies including OSCC. The aim of the present study was to evaluate the expression of miR-486-3p, miR-561-5p, miR-548-3p, and miR-509-5p in tissue biopsy samples with and without OSCC., This case-control study was conducted on 17 healthy and 17 OSCC tissue biopsy samples. The expression of miRNAs was assessed using quantitative real-time PCR (q-RT-PCR) after RNA extraction from normal and cancer tissues and cDNA synthesis., The means of miRNA-486-3p, miR-561-5p, and miR-548-3p expression were significantly different between OSCC and control groups (p < 0.001), but there was no significant difference in means of miR-509-5p expression between OSCC and control groups (p = 0.179)., The findings of this study revealed that the expression of miR-486-3p and miR-561-5p was significantly lower in cancer samples compared to normal tissue samples. On the other hand, miR-548-3p expression increased in the OSCC group compared to the control group.
Publisher MDPI
ISSN/ISBN 2076-0817
edoc-URL https://edoc.unibas.ch/87779/
Full Text on edoc Available
Digital Object Identifier DOI 10.3390/pathogens11020211
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/35215154
ISI-Number MEDLINE:35215154
Document type (ISI) Journal Article
 
   

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