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The Impact of; Bartonella; VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4639388
Author(s) Fromm, Katja; Dehio, Christoph
Author(s) at UniBasel Dehio, Christoph
Fromm, Katja
Year 2021
Title The Impact of; Bartonella; VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells
Journal Frontiers in Microbiology
Volume 12
Pages / Article-Number 762582
Keywords Bartonella effector protein (Bep); VirB/VirD4; bacterial effector protein; bacterial pathogenesis; host-pathogen interaction; type IV secretion system (T4SS)
Abstract Bartonella; spp. are facultative intracellular pathogens that infect a wide range of mammalian hosts including humans. The VirB/VirD4 type IV secretion system (T4SS) is a key virulence factor utilized to translocate; Bartonella; effector proteins (Beps) into host cells in order to subvert their functions. Crucial for effector translocation is the C-terminal Bep intracellular delivery (BID) domain that together with a positively charged tail sequence forms a bipartite translocation signal. Multiple BID domains also evolved secondary effector functions within host cells. The majority of Beps possess an N-terminal filamentation induced by cAMP (FIC) domain and a central connecting oligonucleotide binding (OB) fold. FIC domains typically mediate AMPylation or related post-translational modifications of target proteins. Some Beps harbor other functional modules, such as tandem-repeated tyrosine-phosphorylation (EPIYA-related) motifs. Within host cells the EPIYA-related motifs are phosphorylated, which facilitates the interaction with host signaling proteins. In this review, we will summarize our current knowledge on the molecular functions of the different domains present in Beps and highlight examples of Bep-dependent host cell modulation.
Publisher Frontiers Media
ISSN/ISBN 1664-302X
edoc-URL https://edoc.unibas.ch/87221/
Full Text on edoc Available
Digital Object Identifier DOI 10.3389/fmicb.2021.762582
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34975788
Document type (ISI) Journal Article, Review
 
   

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