Ten millennia of hepatitis B virus evolution
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4638560
Author(s)
Kocher, Arthur; Papac, Luka; Barquera, Rodrigo; Key Felix, M.; Spyrou Maria, A.; Hübler, Ron; Rohrlach Adam, B.; Aron, Franziska; Stahl, Raphaela; Wissgott, Antje; van Bömmel, Florian; Pfefferkorn, Maria; Mittnik, Alissa; Villalba-Mouco, Vanessa; Neumann Gunnar, U.; Rivollat, Maïté; van de Loosdrecht Marieke, S.; Majander, Kerttu; Tukhbatova Rezeda, I.; Musralina, Lyazzat; Ghalichi, Ayshin; Penske, Sandra; Sabin, Susanna; Michel, Megan; Gretzinger, Joscha; Nelson Elizabeth, A.; Ferraz, Tiago; Nägele, Kathrin; Parker, Cody; Keller, Marcel; Guevara Evelyn, K.; Feldman, Michal; Eisenmann, Stefanie; Skourtanioti, Eirini; Giffin, Karen; Gnecchi-Ruscone Guido, Alberto; Friederich, Susanne; Schimmenti, Vittoria; Khartanovich, Valery; Karapetian Marina, K.; Chaplygin Mikhail, S.; Kufterin Vladimir, V.; Khokhlov Aleksandr, A.; Chizhevsky Andrey, A.; Stashenkov Dmitry, A.; Kochkina Anna, F.; Tejedor-Rodríguez, Cristina; de Lagrán Íñigo, García-Martínez; Arcusa-Magallón, Héctor; Garrido-Pena, Rafael; Royo-Guillén José, Ignacio; Nováček, Jan; Rottier, Stéphane; Kacki, Sacha; Saintot, Sylvie; Kaverzneva, Elena; Belinskiy Andrej, B.; Velemínský, Petr; Limburský, Petr; Kostka, Michal; Loe, Louise; Popescu, Elizabeth; Clarke, Rachel; Lyons, Alice; Mortimer, Richard; Sajantila, Antti; de Armas Yadira, Chinique; Hernandez Godoy Silvia, Teresita; Hernández-Zaragoza Diana, I.; Pearson, Jessica; Binder, Didier; Lefranc, Philippe; Kantorovich Anatoly, R.; Maslov Vladimir, E.; Lai, Luca; Zoledziewska, Magdalena; Beckett Jessica, F.; Langová, Michaela; Danielisová, Al�běta; Ingman, Tara; Atiénzar Gabriel, García; de Miguel Ibáñez Maria, Paz; Romero, Alejandro; Sperduti, Alessandra; Beckett, Sophie; Salter Susannah, J.; Zilivinskaya Emma, D.; Vasil'ev Dmitry, V.; von Heyking, Kristin; Burger Richard, L.; Salazar Lucy, C.; Amkreutz, Luc; Navruzbekov, Masnav; Rosenstock, Eva; Alonso-Fernández, Carmen; Slavchev, Vladimir; Kalmykov Alexey, A.; Atabiev Biaslan, Ch; Batieva, Elena; Calmet , Micaela Alvarez; Llamas, Bastien; Schultz, Michael; Krauß, Raiko; Jiménez-Echevarría, Javier; Francken, Michael; Shnaider, Svetlana; de Knijff, Peter; Altena, Eveline; Van de Vijver, Katrien; Fehren-Schmitz, Lars; Tung Tiffiny, A.; Lösch, Sandra; Dobrovolskaya, Maria; Makarov, Nikolaj; Read, Chris; Van Twest, Melanie; Sagona, Claudia; Ramsl Peter, C.; Akar, Murat; Yener, K. Aslihan; Ballestero , Eduardo Carmona; Cucca, Francesco; Mazzarello, Vittorio; Utrilla, Pilar; Rademaker, Kurt; Fernández-Domínguez, Eva; Baird, Douglas; Semal, Patrick; Márquez-Morfín, Lourdes; Roksandic, Mirjana; Steiner, Hubert; Salazar-García , Domingo Carlos; Shishlina, Natalia; Erdal Yilmaz, Selim; Hallgren, Fredrik; Boyadzhiev, Yavor; Boyadzhiev, Kamen; Küßner, Mario; Sayer, Duncan; Onkamo, Päivi; Skeates, Robin; Rojo-Guerra, Manuel; Buzhilova, Alexandra; Khussainova, Elmira; Djansugurova , Leyla B.; Beisenov , Arman Z.; Samashev, Zainolla; Massy, Ken; Mannino, Marcello; Moiseyev, Vyacheslav; Mannermaa, Kristiina; Balanovsky, Oleg; Deguilloux, Marie-France; Reinhold, Sabine; Hansen, Svend; Kitov Egor, P.; Dobes, Miroslav; Ernée, Michal; Meller, Harald; Alt , Kurt W.; Prüfer, Kay; Warinner, Christina; Schiffels, Stephan; Stockhammer , Philipp W.; Bos, Kirsten; Posth, Cosimo; Herbig, Alexander; Haak, Wolfgang; Krause, Johannes; Kühnert, Denise
Author(s) at UniBasel
Alt, Kurt
Year
2021
Title
Ten millennia of hepatitis B virus evolution
Journal
Science
Volume
374
Number
6564
Pages / Article-Number
182-188
Mesh terms
American Indians or Alaska Natives; Americas; Asia; Asians; Communicable Diseases, Emerging, virology; Europe; Evolution, Molecular; Genetic Variation; Genomics; Hepatitis B, virology; Hepatitis B virus, genetics; History, Ancient; Humans; Paleontology; Phylogeny; Whites
Abstract
Hepatitis B virus (HBV) infections represent a worldwide human health concern. To study the history of this pathogen, Kocher et al . identified 137 human remains with detectable levels of virus dating between 400 and 10,000 years ago. Sequencing and analyses of these ancient viruses suggested a common ancestor between 12,000 and 20,000 years ago. There is no evidence indicating that HBV was present in the earliest humans as they spread out of Africa; however, HBV was likely present in human populations before farming. Furthermore, the virus was present in the Americas by about 9000 years ago, representing a lineage sister to the viral strains found in Eurasia that diverged about 20,000 years ago.
Publisher
American Association for the Advancement of Science
URL
https://doi.org/10.1126/science.abi5658
edoc-URL
https://edoc.unibas.ch/86959/
Full Text on edoc
No
Digital Object Identifier DOI
10.1126/science.abi5658
PubMed ID
http://www.ncbi.nlm.nih.gov/pubmed/34618559
ISI-Number
WOS:000704920400041
Document type (ISI)
Historical Article, Journal Article
