Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4638427
Author(s) Hander, Tim; Fernandez-Fernandez, Alvaro D.; Kumpf, Robert P.; Willems, Patrick; Schatowitz, Hendrik; Rombaut, Debbie; Staes, An; Nolf, Jonah; Pottie, Robin; Yao, Panfeng; Goncalves, Amanda; Pavie, Benjamin; Boller, Thomas; Gevaert, Kris; Van Breusegem, Frank; Bartels, Sebastian; Stael, Simon
Author(s) at UniBasel Boller, Thomas
Hander, Tim
Merker, Sebastian
Schatowitz, Hendrik
Year 2019
Title Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides
Journal Science
Volume 363
Number 6433
Pages / Article-Number 1301-+
Mesh terms Amino Acid Sequence; Arabidopsis, immunology; Arabidopsis Proteins, metabolism; Calcium, metabolism; Cysteine Endopeptidases, metabolism; Cytosol, enzymology; Immunomodulation; Oligopeptides, metabolism; Plant Immunity; Protein Precursors, metabolism
Abstract Physical damage to cells leads to the release of immunomodulatory peptides to elicit a wound defense response in the surrounding tissue. In Arabidopsis thaliana, the plant elicitor peptide 1 (Pep1) is processed from its protein precursor, PRECURSOR OF PEP1 (PROPEP1). We demonstrate that upon damage, both at the tissue and single-cell levels, the cysteine protease METACASPASE4 (MC4) is instantly and spatiotemporally activated by binding high levels of Ca2+ and is necessary and sufficient for Pep1 maturation. Cytosol-localized PROPEP1 and MC4 react only after loss of plasma membrane integrity and prolonged extracellular Ca2+ entry. Our results reveal that a robust mechanism consisting of conserved molecular components links the intracellular and Ca2+-dependent activation of a specific cysteine protease with the maturation of damage-induced wound defense signals.
ISSN/ISBN 0036-8075
Full Text on edoc No
Digital Object Identifier DOI 10.1126/science.aar7486
PubMed ID
ISI-Number WOS:000462016400043
Document type (ISI) Journal Article

MCSS v5.8 PRO. 0.435 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |