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Altered Cardiovascular Reactivity to and Recovery from Cold Face Test-Induced Parasympathetic Stimulation in Essential Hypertension.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4636178
Author(s) Walther, Lisa-Marie; von Känel, Roland; Heimgartner, Nadja; Zuccarella-Hackl, Claudia; Ehlert, Ulrike; Wirtz, Petra H
Author(s) at UniBasel Heimgartner, Nadja
Year 2021
Title Altered Cardiovascular Reactivity to and Recovery from Cold Face Test-Induced Parasympathetic Stimulation in Essential Hypertension.
Journal Journal of clinical medicine
Volume 10
Number 12
Pages / Article-Number 2714
Keywords Cold Face Test (CFT); cardiovascular reactivity; chronic stress; hypertension; parasympathetic stimulation
Abstract

Essential hypertension is associated with increased sympathetic and diminished parasympathetic activity as well as impaired reactivity to sympathetic stimulation. However, reactivity and recovery from parasympathetic stimulation in hypertension are unknown. We investigated reactivity and recovery to primarily parasympathetic stimulation by Cold Face Test (CFT) in essential hypertension. Moreover, we tested whether chronic stress modulates CFT-reactivity dependent on hypertension status. The CFT was conducted by applying a cold face-mask for 2 min in 24 unmedicated, otherwise healthy hypertensive men and in 24 normotensive controls. Systolic and diastolic blood pressure (BP) and heart rate (HR) were measured repeatedly. Chronic stress was assessed with the Trier-Inventory-for-Chronic-Stress-Screening-Scale. Hypertensives did not exhibit diastolic BP decreases after CFT-cessation (; p; = 0.59) as did normotensives (; p; = 0.002) and failed to show HR decreases in immediate response to CFT (; p; = 0.62) when compared to normotensives (; p; < 0.001). Systolic BP reactivity and recovery patterns did not differ between hypertensives and normotensives (; p; = 0.44). Chronic stress moderated HR (; p; = 0.045) but not BP CFT-reactivity (; p; 's > 0.64) with chronically stressed normotensives showing similar HR reactivity as hypertensives. Our findings indicate impaired diastolic BP and HR reactivity to and recovery from CFT in hypertensives and a moderating effect of chronic stress on HR reactivity potentially reflecting reduced relaxation ability of the cardiovascular system.

ISSN/ISBN 2077-0383
Full Text on edoc
Digital Object Identifier DOI 10.3390/jcm10122714
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34205387
   

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