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Prodrugs of E-selectin Antagonists with Enhanced Pharmacokinetic Properties.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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ID |
4635455 |
Author(s) |
Dätwyler, Philipp; Jiang, Xiaohua; Wagner, Beatrice; Varga, Norbert; Mühlethaler, Tobias; Hostettler, Katja; Rabbani, Said; Schwardt, Oliver; Ernst, Beat |
Author(s) at UniBasel |
Ernst, Beat Dätwyler, Philipp Jiang, Xiaohua Wagner, Beatrice Varga, Norbert Mühlethaler, Tobias Rabbani, Said Schwardt, Oliver
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Year |
2022 |
Title |
Prodrugs of E-selectin Antagonists with Enhanced Pharmacokinetic Properties. |
Journal |
ChemMedChem |
Volume |
17 |
Pages / Article-Number |
e202100634 (1 of 7) |
Keywords |
Absorption; Ester prodrugs; Glycomimetics; Lead optimization; Metabolism |
Abstract |
Because of their large polar surface area, carbohydrates often exhibit insufficient pharmacokinetic properties. Specifically, the carboxylic acid function of the tetrasaccharide sialyl Lewis; x; , a pharmacophore crucial for the formation of a salt bridge with selectins, prevents oral availability. A common approach is the transfer of carboxylic acid into ester prodrugs. Once the prodrug is either actively or passively absorbed, the active principle is released by hydrolysis. In the present study, ester prodrugs of selectin antagonists with aliphatic promoieties were synthesized and their potential for oral availability was investigated in vitro and in vivo. The addition of lipophilic ester moieties to overcome insufficient lipophilicity improved passive permeation into enterocytes, however at the same time supported efflux back to the small intestines as well as oxidation into non-hydrolysable metabolites. In summary, our examples demonstrate that different modifications of carbohydrates can result in opposing effects and have to be studied in their entirety. |
ISSN/ISBN |
1860-7187 |
Full Text on edoc |
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Digital Object Identifier DOI |
10.1002/cmdc.202100634 |
PubMed ID |
http://www.ncbi.nlm.nih.gov/pubmed/34870892 |
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09/05/2024
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