Logo der Universität Basel

Research Database / FORSCHUNGSDATENBANK 
PRINTDOC
 
Publication 4631696 | Verified
 

Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
A Personal Account on Industrial Collaborations in the Field of C-H Activation
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4631696
Author(s) Baudoin, Olivier
Author(s) at UniBasel Baudoin, Olivier
Year 2021
Title A Personal Account on Industrial Collaborations in the Field of C-H Activation
Journal Chimia
Volume 75
Number 11
Pages / Article-Number 967-971
Mesh terms Catalysis; Follow-Up Studies; Transition Elements
Abstract In recent years, transition-metal-catalyzed C-H functionalization has emerged as a potentially greener alternative to classic cross-couplings and as a powerful tool to access complex functional molecules with improved step-economy. This short account relates our experience of industrial collaborations in C(sp³)-H bond activation, which were key to the development of this topic in our group. The synthesis of the antianginal drug Ivabradine led us to develop a general approach to benzocyclobutenes, which were further employed in peri cyclic reactions. A follow-up study led us to discover a new method to construct arylcyclopropanes; via; double C-H activation and the coupling of two alkyl groups. Finally, targeting the herbicide Indaziflam contributed to develop C(sp³)-H activation as a powerful tool to access a variety of relevant indane motifs. We hope that these successful stories will help to stimulate further fruitful Industry-Academia collaborations in the field of synthetic chemistry.
Publisher Schweizerische Chemische Gesellschaft
ISSN/ISBN 0009-4293
edoc-URL https://edoc.unibas.ch/85356/
Full Text on edoc Available
Digital Object Identifier DOI 10.2533/chimia.2021.967
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34798919
ISI-Number MEDLINE:34798919
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.356 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
25/04/2024