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Assessing medication adherence barriers to short-term oral antibiotic treatment in primary care-development and validation of a self-report questionnaire (BIOTICA)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4626497
Author(s) Haag, Melanie; Hersberger, Kurt E; Arnet, Isabelle
Author(s) at UniBasel Arnet, Isabelle
Hersberger, Kurt
Haag, Melanie
Year 2021
Title Assessing medication adherence barriers to short-term oral antibiotic treatment in primary care-development and validation of a self-report questionnaire (BIOTICA)
Journal Int J Environ Res Pub Health
Volume 18
Number 15
Pages / Article-Number 7768
Keywords medication adherence; medicines optimization; patient-centred pharmaceutical care; pharmaceutical care; responsibilities/roles in pharmaceutical care
Mesh terms Anti-Bacterial Agents, therapeutic use; Female; Humans; Male; Medication Adherence; Primary Health Care; Reproducibility of Results; Self Report; Surveys and Questionnaires
Abstract

Pharmacists are increasingly involved in strategies to fight antimicrobial resistance by ensuring optimised antibiotic (AB) use, including adherence support. Successful adherence interventions should be tailored to patients' barriers and validated instruments are needed. This study aimed to identify adherence barriers to AB treatment, develop a self-report questionnaire, and validate it in outpatients.; Adherence barriers were identified through a systematic literature search and focus group discussion. Unmodifiable and irrelevant barriers were excluded from further processing. A validation study assessed the questionnaire's internal reliability and construct validity by comparing the questionnaire's score with electronically monitored adherence data.; A 15-item questionnaire was created. Overall, 68 patients were included in the construct validation analysis (60.3% female). The mean consecutive taking adherence was 88% and the most frequently reported barriers were "worries about side-effects" (37%) and "having swallowing difficulties" (19%). Three items were excluded from the questionnaire, which was supported by an increase of Cronbach's alpha (0.69 to 0.70). The 12-item version's score correlated significantly with medication adherence rate (r = -0.34,; p; < 0.01).; The self-report questionnaire is a reliable and valid tool to pre-emptively assess adherence barriers in outpatients prescribed ABs. In the future, appropriate adherence interventions can be matched to barriers and tested in a pilot intervention study.

ISSN/ISBN 1660-4601
Full Text on edoc
Digital Object Identifier DOI 10.3390/ijerph18157768
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34360062
   

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