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Organophotocatalytic Aerobic Oxygenation of Phenols in a Visible-Light Continuous-Flow Photoreactor
Journal
Chemistry - A European Journal
Volume
27
Number
38
Pages / Article-Number
9748-9752
Keywords
aerobic oxidation; phenol; photooxygenation; singlet oxygen; vitamins
Mesh terms
Benzoquinones; Light; Phenol; Phenols; Singlet Oxygen
Abstract
A mild photocatalytic phenol oxygenation enabled by a continuous-flow photoreactor using visible light and pressurized air is described herein. Products for wide-ranging applications, including the synthesis of vitamins, were obtained in high yields by precisely controlling principal process parameters. The reactor design permits low organophotocatalyst loadings to generate singlet oxygen. It is anticipated that the efficient aerobic phenol oxygenation to benzoquinones and p-quinols contributes to sustainable synthesis.
