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Home delivery: Bacterial sRNA mediated treatment of intestinal bowel disease (Freenovation Grant, Miro Plum and Maxim Kolesnikov)
Third-party funded project
Project title Home delivery: Bacterial sRNA mediated treatment of intestinal bowel disease (Freenovation Grant, Miro Plum and Maxim Kolesnikov)
Principal Investigator(s) Basler, Marek
Co-Investigator(s) Kolesnikov, Maxim
Plum, Miro Thorsten Wilhelm
Organisation / Research unit Departement Biozentrum / Infection Biology (Basler)
Department Departement Biozentrum / Infection Biology (Basler)
Project start 01.08.2021
Probable end 31.07.2023
Status Completed
Abstract

Inflammatory bowel disease is characterized by persistent inflammation of the colon and represents an increasing problem worldwide. Existing treatments are broad-acting, unspecific and are limited to temporary relief of symptoms. Moreover, the disease is highly heterogeneous, with a variety of possible causes that range from genetic to environmental. In our project, we will engineer a bacterium that secretes anti-inflammatory RNA in extracellular vesicles. Such a “living pill” may pave the way for further applications that involve RNA dependent regulation.

Keywords anti-inflammation, bacterial sRNA, Inflammatory bowel disease
Financed by Private Sector / Industry
   

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28/03/2024