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Home delivery: Bacterial sRNA mediated treatment of intestinal bowel disease (Freenovation Grant, Miro Plum and Maxim Kolesnikov)
Third-party funded project |
Project title |
Home delivery: Bacterial sRNA mediated treatment of intestinal bowel disease (Freenovation Grant, Miro Plum and Maxim Kolesnikov) |
Principal Investigator(s) |
Basler, Marek
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Co-Investigator(s) |
Kolesnikov, Maxim Plum, Miro Thorsten Wilhelm
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Organisation / Research unit |
Departement Biozentrum / Infection Biology (Basler) |
Department |
Departement Biozentrum / Infection Biology (Basler) |
Project start |
01.08.2021 |
Probable end |
31.07.2023 |
Status |
Completed |
Abstract |
Inflammatory bowel disease is characterized by persistent inflammation of the colon and represents an increasing problem worldwide. Existing treatments are broad-acting, unspecific and are limited to temporary relief of symptoms. Moreover, the disease is highly heterogeneous, with a variety of possible causes that range from genetic to environmental. In our project, we will engineer a bacterium that secretes anti-inflammatory RNA in extracellular vesicles. Such a “living pill” may pave the way for further applications that involve RNA dependent regulation. |
Keywords |
anti-inflammation, bacterial sRNA, Inflammatory bowel disease |
Financed by |
Private Sector / Industry
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28/03/2024
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