Severe Adverse Drug Reactions to Quetiapine in Two Patients Carrying; CYP2D6; *4 Variants: A Case Report
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4622205
Author(s) Stäuble, Céline K.; Lampert, Markus L.; Mikoteit, Thorsten; Hatzinger, Martin; Hersberger, Kurt E.; Meyer Zu Schwabedissen, Henriette E.
Author(s) at UniBasel Meyer zu Schwabedissen, Henriette
Stäuble, Céline
Lampert, Markus Leopold
Hersberger, Kurt
Year 2021
Title Severe Adverse Drug Reactions to Quetiapine in Two Patients Carrying; CYP2D6; *4 Variants: A Case Report
Journal International Journal of Molecular Siences
Volume 22
Number 12
Pages / Article-Number 6480
Keywords CYP2D6; CYP3A4; adverse drug reaction; antipsychotics; depression; neuroleptics; pharmaceutical care; pharmacogenetics; psychiatry; quetiapine.
Mesh terms Alleles; Antipsychotic Agents, metabolism; Cytochrome P-450 CYP2D6, metabolism; Drug-Related Side Effects and Adverse Reactions, metabolism; Genetic Association Studies; Genetic Variation; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Quetiapine Fumarate, metabolism; Severity of Illness Index
Abstract We report two cases of patients who developed severe adverse drug reactions including persistent movement disorders, nausea, and vertigo during treatment with quetiapine at maximum daily doses ranging between 300 and 400 mg. The extensive hepatic metabolism of quetiapine is mainly attributed to cytochrome P450 3A4 (CYP3A4). However, there is recent evidence supporting the idea of CYP2D6 playing a role in the clearance of the quetiapine active metabolite norquetiapine. Interestingly, both patients we are reporting of are carriers of the CYP2D6 *4 variant, predicting an intermediate metabolizer phenotype. Additionally, co-medication with a known CYP2D6 inhibitor and renal impairment might have further affected quetiapine pharmacokinetics. The herein reported cases could spark a discussion on the potential impact of a patient's pharmacogenetic predisposition in the treatment with quetiapine. However, further studies are warranted to promote the adoption of pharmacogenetic testing for the prevention of drug-induced toxicities associated with quetiapine.
Publisher MDPI
ISSN/ISBN 1661-6596 ; 1422-0067
edoc-URL https://edoc.unibas.ch/83968/
Full Text on edoc No
Digital Object Identifier DOI 10.3390/ijms22126480
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34204223
ISI-Number WOS:000666278600001
Document type (ISI) Article
 
   

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07/12/2022