Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Hydroxychloroquine immediate release tablets: Formulation and evaluation of a solid dosage form
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4617703
Author(s) Einfalt, Tomaz; Detampel, Pascal; Häussinger, Daniel; Casper, Jens; Meier, Christoph; Puchkov, Maxim; Huwyler, Jörg
Author(s) at UniBasel Huwyler, Jörg
Einfalt, Tomaz
Detampel, Pascal
Häussinger, Daniel
Casper, Jens
Meier, Christoph R.
Puchkov, Maxim
Year 2021
Title Hydroxychloroquine immediate release tablets: Formulation and evaluation of a solid dosage form
Journal ChemRxiv Preprint
Keywords hydroxychloroquine, tablet, immediate release, solid dosage form
Abstract Hydroxychloroquine (HCQ) is a quinoline derivate used for the treatment of malaria and rheumatoid disorders. During early phases of the SARS - CoV2 (COVID - 19) pandemic, preliminary and later not substantiated reports suggested that HCQ might benefit COVID - 19 patients. This ha d sparked a worldwide and rapidly rising demand for HCQ drug products. Consequently, patients with pre - existing rheumatic diseases in Switzerland wer e confronted with an acute drug shortage . We have therefore designed, produced and characterized a generic HCQ drug formulation. The proposed HCQ formulation can be manufactured by using a minimal number of operation steps ( mixing, wet granulation, sieving , blending, compression) and readily available pharmaceutical excipients. HCQ tablets were manufactured by granulation of the active pharmaceutical ingredient ( API ) , blending with the external phase and compaction using a non instrumented single punch tab let press. Analytics and identification of the API was performed by a combination of NMR, ESI - MS, FT IR and HPLC. HCQ tablets met the quality criteria for an immediate release HCQ dosage form. We hope th at free access to non - proprietary protocols covering analytical procedures, formulation design, and manufacturing instructions for HCQ tablets will help to bridge existing and future supply chain gaps.
URL https://chemrxiv.org/articles/preprint/Hydroxychloroquine_Immediate_Release_Tablets_Formulation_and_Evaluation_of_a_Solid_Dosage_Form/14170508/1
edoc-URL https://edoc.unibas.ch/82329/
Full Text on edoc No
Digital Object Identifier DOI 10.26434/chemrxiv.14170508.v1
 
   

MCSS v5.8 PRO. 0.323 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/03/2024