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Adaptation of human enterovirus to warm environments leads to resistance against chlorine disinfection
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4616853
Author(s) Carratalà, Anna; Bachmann, Virginie; Julian, Timothy R.; Kohn, Tamar
Author(s) at UniBasel Julian, Timothy
Year 2020
Title Adaptation of human enterovirus to warm environments leads to resistance against chlorine disinfection
Journal Environmental science
Volume 54
Number 18
Pages / Article-Number 11292-11300
Mesh terms Chlorine; Disinfection; Enterovirus; Enterovirus B, Human; Humans; Viruses
Abstract Sunlight, temperature, and microbial grazing are among the environmental factors promoting the inactivation of viral pathogens in surface waters. Globally, these factors vary across time and space. The persistence of viral pathogens, and ultimately their ecology and dispersion, hinges on their ability to withstand the environmental conditions encountered. To understand how virus populations evolve under changing environmental conditions, we experimentally adapted echovirus 11 (E11) to four climate regimes. Specifically, we incubated E11 in lake water at 10 and 30 °C and in the presence and absence of sunlight. Temperature was the main driver of adaptation, resulting in an increased thermotolerance of the 30 °C adapted populations, whereas the 10 °C adapted strains were rapidly inactivated at higher temperatures. This finding is consistent with a source-sink model in which strains emerging in warm climates can persist in temperate regions, but not vice versa. A microbial risk assessment revealed that the enhanced thermotolerance increases the length of time in which there is an elevated probability of illness associated with swimming in contaminated water. Notably, 30 °C-adapted viruses also exhibited an increased tolerance toward disinfection by free chlorine. Viruses adapting to warm environments may thus become harder to eliminate by common disinfection strategies.
ISSN/ISBN 1093-829X
edoc-URL https://edoc.unibas.ch/82075/
Full Text on edoc No
Digital Object Identifier DOI 10.1021/acs.est.0c03199
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/32875801
ISI-Number WOS:000572834700032
Document type (ISI) Journal Article
 
   

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29/03/2024