Numerous publications call for innovation based on integrated care principles, investment in self-management and use of eHealth to improve outcomes for allogeneic Stem Cell Transplant (alloSCT), patients with complex care needs and multiple morbidities. Combining implementation science with computer and behavioural science methods, we will implement and evaluate the newly developed and further adapted eHealth facilitated SMILe–Integrated Care Model (SMILe–ICM) for alloSCT patients at our second participating center at the University Hospital Basel (USB, Switzerland), aiming to reduce first year post-alloSCT re-hospitalizations.

The SMILe–ICM is the first theory-based comprehensive eHealth supported integrated care model, which was developed and further adapted on the basis of context analyses to understand practice patterns /context of alloSCT follow-up care and the level of technology openness of patients and clinicians. The SMILe-ICM comprehensively addresses alloSCT needs by optimizing care coordination and care processes, and by reducing response times in cases where the patient’s condition is deteriorating at home.

SMILe-ICM is currently evaluated in terms of both implementation and effectiveness outcomes in a hybrid 1 implementation effectiveness design at USB (started 04/2021). In addition to targeting one primary outcome, re-hospitalization rate, our secondary outcomes will include effectiveness (e.g., health care costs, medication adherence) and implementation outcomes (e.g., acceptability, fidelity).