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Can Measurements of Inflammatory Biomarkers be Used to Spot Respiratory Viral Infections?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4616579
Author(s) Sinha, Anirban; Lutter, René; Dekker, Tamara; Dierdorp, Barbara; Sterk, Peter J.; Delgado-Eckert, Edgar; Frey, Urs
Author(s) at UniBasel Frey, Urs Peter
Delgado-Eckert, Edgar
Year 2020
Title Can Measurements of Inflammatory Biomarkers be Used to Spot Respiratory Viral Infections?
Journal Viruses
Volume 12
Number 10
Pages / Article-Number 1175
Keywords detection of viral infections; inflammatory biomarkers; lung function; rhinovirus; viral respiratory infections
Abstract Accurate detection of human respiratory viral infections is highly topical. We investigated how strongly inflammatory biomarkers (FeNO, eosinophils, neutrophils, and cytokines in nasal lavage fluid) and lung function parameters change upon rhinovirus 16 infection, in order to explore their potential use for infection detection. To this end, within a longitudinal cohort study, healthy and mildly asthmatic volunteers were experimentally inoculated with rhinovirus 16, and time series of these parameters/biomarkers were systematically recorded and compared between the pre- and post-infection phases of the study, which lasted two months and one month, respectively. We found that the parameters'/biomarkers' ability to discriminate between the infected and the uninfected state varied over the observation time period. Consistently over time, the concentration of cytokines, in nasal lavage fluid, showed moderate to very good discrimination performance, thereby qualifying for disease progression monitoring, whereas lung function and FeNO, while quickly and non-invasively measurable using cheap portable devices (e.g., at airports), performed poorly.
Publisher MDPI
ISSN/ISBN 1999-4915
edoc-URL https://edoc.unibas.ch/82039/
Full Text on edoc Available
Digital Object Identifier DOI 10.3390/v12101175
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/33080844
 
   

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