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Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4615392
Author(s) Beck, Katharina R.; Odermatt, Alex
Author(s) at UniBasel Odermatt, Alex
Year 2021
Title Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess
Journal Molecular and Cellular Endocrinology
Volume 524
Pages / Article-Number 111168
Keywords 11β-hydroxysteroid dehydrogenase; Adverse drug reaction; Azole antifungal; CYP11B; Hypertension; Mineralocorticoid excess
Abstract The syndromes of mineralocorticoid excess describe a heterogeneous group of clinical manifestations leading to endocrine hypertension, typically either through direct activation of mineralocorticoid receptors or indirectly by impaired pre-receptor enzymatic regulation or through disturbed renal sodium homeostasis. The phenotypes of these disorders can be caused by inherited gene variants and somatic mutations or may be acquired upon exposures to exogenous substances. Regarding the latter, the symptoms of an acquired mineralocorticoid excess have been reported during treatment with azole antifungal drugs. The current review describes the occurrence of mineralocorticoid excess particularly during the therapy with posaconazole and itraconazole, addresses the underlying mechanisms as well as inter- and intra-individual differences, and proposes a therapeutic drug monitoring strategy for these two azole antifungals. Moreover, other therapeutically used azole antifungals and ongoing efforts to avoid adverse mineralocorticoid effects of azole compounds are shortly discussed.
Publisher Elsevier
ISSN/ISBN 0303-7207
edoc-URL https://edoc.unibas.ch/81721/
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/j.mce.2021.111168
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/33484741
Document type (ISI) Journal Article
 
   

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