The catalytic mechanism of sulfoxide synthases

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The catalytic mechanism of sulfoxide synthases

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4614558
Author(s)	Stampfli, Anja R.; Seebeck, Florian P.
Author(s) at UniBasel	Seebeck, Florian Peter Stampfli, Anja
Year	2020
Title	The catalytic mechanism of sulfoxide synthases
Journal	Current Opinion in Chemical Biology
Volume	59
Pages / Article-Number	111-118
Keywords	Carbonesulfur bond formation; Enzymology; Ergothioneine; Non-heme iron enzyme
Abstract	Sulfoxide synthases are non-heme iron enzymes that catalyze oxidative carbonsulfur bond formation in the biosynthesis of thiohistidines such as ergothioneine and ovothiol. The catalytic mechanism of these enzymes has been studied by protein crystallography, steady-state kinetics, non-natural amino acid incorporation and computational modeling. This review discusses the current status of this research and also highlights similarities between the CS bond forming activity of sulfoxide synthases with that of synthetic coordination compounds.
Publisher	Elsevier
ISSN/ISBN	1367-5931 ; 1879-0402
edoc-URL	https://edoc.unibas.ch/81366/
Full Text on edoc	No
Digital Object Identifier DOI	10.1016/j.cbpa.2020.06.007
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/32726707

12/05/2024

Research Database / FORSCHUNGSDATENBANK