Structural basis of ergothioneine biosynthesis

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Structural basis of ergothioneine biosynthesis

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4614556
Author(s)	Stampfli, Anja R.; Blankenfeldt, Wulf; Seebeck, Florian P.
Author(s) at UniBasel	Seebeck, Florian Peter Stampfli, Anja
Year	2020
Title	Structural basis of ergothioneine biosynthesis
Journal	Current Opinion in Structural Biology
Volume	65
Pages / Article-Number	1-8
Abstract	Ergothioneine is a sulfur-containing histidine derivative synthesized by many bacteria and most fungi but it also finds its way into human tissue by way of specific absorption from the diet. The precise role of ergothioneine is not yet known but there is growing evidence that it plays a role as an antioxidant protecting human cells from oxidative stress and pathogenic bacteria from host defenses. In this review we highlight recent advances in understanding the structural basis of ergothioneine biosynthesis. In addition to unusual carbon-sulfur bond forming enzymology this research has revealed that ergothioneine biosynthesis has emerged at least three times by independent molecular evolution.
Publisher	Elsevier
ISSN/ISBN	0959-440X ; 1879-033X
edoc-URL	https://edoc.unibas.ch/81365/
Full Text on edoc	No
Digital Object Identifier DOI	10.1016/j.sbi.2020.04.002
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/32408082
Document type (ISI)	Journal Article, Review

03/05/2024

Research Database / FORSCHUNGSDATENBANK