Convergent Evolution of Fungal Cysteine Dioxygenases

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Convergent Evolution of Fungal Cysteine Dioxygenases

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4614554
Author(s)	Flückger, Sebastian; Igareta, Nico V.; Seebeck, Florian P.
Author(s) at UniBasel	Seebeck, Florian Peter Igareta, Nico Valerio
Year	2020
Title	Convergent Evolution of Fungal Cysteine Dioxygenases
Journal	ChemBioChem
Volume	21
Number	21
Pages / Article-Number	3082-3086
Keywords	agaricomycetes; antioxidants; cysteine dioxygenases; ergothioneine; non-heme iron enzyme
Abstract	Cupin-type cysteine dioxygenases (CDOs) are non-heme iron enzymes that occur in animals, plants, bacteria and in filamentous fungi. In this report, we show that agaricomycetes contain an entirely unrelated type of CDO that emerged by convergent evolution from enzymes involved in the biosynthesis of ergothioneine. The activity of this CDO type is dependent on the ergothioneine precursor N-α-trimethylhistidine. The metabolic link between ergothioneine production and cysteine oxidation suggests that the two processes might be part of the same chemical response in fungi, for example against oxidative stress.
Publisher	Wiley
ISSN/ISBN	1439-4227 ; 1439-7633
edoc-URL	https://edoc.unibas.ch/81364/
Full Text on edoc	No
Digital Object Identifier DOI	10.1002/cbic.202000317
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/32543095
Document type (ISI)	Journal Article

12/05/2024

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