Catalyst-Controlled Transannular Polyketide Cyclization Cascades: Selective Folding of Macrocyclic Polyketides

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Catalyst-Controlled Transannular Polyketide Cyclization Cascades: Selective Folding of Macrocyclic Polyketides

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4613472
Author(s)	Raps, Felix C.; Fäseke, Vincent C.; Häussinger, Daniel; Sparr, Christof
Author(s) at UniBasel	Sparr, Christof Häussinger, Daniel
Year	2020
Title	Catalyst-Controlled Transannular Polyketide Cyclization Cascades: Selective Folding of Macrocyclic Polyketides
Journal	Angewandte Chemie International Edition
Volume	59
Number	42
Pages / Article-Number	18390-18394
Keywords	biomimetic synthesis; cyclization; natural products; polyketides; regioselectivity
Abstract	The biomimetic synthesis of aromatic polyketides from macrocyclic substrates by means of catalyst-controlled transannular cyclization cascades is described. The macrocyclic substrates, which feature increased stability and fewer conformational states, were thereby transformed into several distinct polyketide scaffolds. The catalyst-controlled transannular cyclizations selectively led to aromatic polyketides with a defined folding and oxygenation pattern, thus emulating β-keto-processing steps of polyketide biosynthesis.
Publisher	Wiley
ISSN/ISBN	1433-7851 ; 1521-3773
edoc-URL	https://edoc.unibas.ch/81051/
Full Text on edoc	Restricted
Digital Object Identifier DOI	10.1002/anie.202005733
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/32666634
Document type (ISI)	Journal Article

26/04/2024

Research Database / FORSCHUNGSDATENBANK