ToxOligo addresses an important knowledge gap by characterizing toxicological properties of oligomers released from food contact materials (FCM) such as plastics, adhesives, printing inks and coatings. Despite known high levels in FCM, these substances are toxicologically poorly investigated, preventing adequate risk assessment. A systematic review of the literature and expert interviews will provide insight on available knowledge of types of structures involved, exposure estimates and toxicological information. Physico-chemical and ADME properties, reactivity of building blocks, stability of oligomers, genotoxicity, endocrine disrupting potentials, and chronic and developmental toxicity will be predicted by in silico methods. Hazard profiles will be established for relevant selected oligomers using in vitro assays on general cytotoxicity, cellular stress pathways, neuronal cell toxicity, macrophage activation, and endocrine regulation. Selected FCM extracts will be considered to identify potentially hazardous materials. Levels of concern will be estimated, information gaps identified, and recommendations for follow-on toxicological analyses and an evaluation concept for safety assessment of oligomers will be proposed.