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Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4611147
Author(s) Rothen, Jean-Pierre; Rutishauser, Jonas; Walter, Philipp N.; Hersberger, Kurt E.; Arnet, Isabelle
Author(s) at UniBasel Hersberger, Kurt
Rothen, Jean-Pierre
Arnet, Isabelle
Walter, Philipp
Year 2020
Title Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial
Journal BMC Pharmacology & Toxicology
Volume 21
Number 1
Pages / Article-Number 51
Keywords Adherence; Cholecalciferol; Dosage frequency; Formulation; Oral intermittent treatment; Preference
Mesh terms Administration, Oral; Aged; Cross-Over Studies; Dietary Supplements; Dosage Forms; Drug Administration Schedule; Female; Focus Groups; Humans; Male; Medication Adherence; Middle Aged; Vitamin D, blood; Vitamins, blood
Abstract To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration.; A focus group of stakeholders aimed at preparing the design of an interventional, randomized, cross-over study with 2 ◊ 2 groups obtaining monthly or weekly vitamin D products in liquid or solid form for 3 months each. Dosage corresponds to cumulated amount of recommended 800 IU daily (5.600 IU weekly / 24.000 IU monthly). Main inclusion criteria were a vitamin D serum value < 50 nmol/l and age ≥ 18 years. Primary endpoint was adherence, secondary endpoints were preferences and vitamin D serum levels.; The focus group reached consensus for preference of a monthly administration of solid forms to adults. Full datasets were obtained from 97 participants. Adherence was significantly higher with monthly (79.5-100.0%) than weekly (66.4-98.1%) administration. Vitamin D levels increased significantly (p 75 nmol/l was achieved by 32% after 3 months and by 50% after 6 months. Preferred formulation was solid form (tablets, capsules) for 71% of participants, and preferred dosage frequency was monthly for 39% of participants.; Monthly oral vitamin D in solid form lead to the highest adherence, and is preferred by the participants. However, only one third of study participants achieved values in the optimal range of > 75 nmol/l cholecalciferol using weekly or monthly administration providing an average daily cholecalciferol dose of 800 IU.
Publisher BioMed Central
ISSN/ISBN 2050-6511
edoc-URL https://edoc.unibas.ch/80255/
Full Text on edoc No
Digital Object Identifier DOI 10.1186/s40360-020-00430-5
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/32653031
Document type (ISI) Journal Article, Randomized Controlled Trial
 
   

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