Novel CPET Reference Values in Healthy Adults: Associations with Physical Activity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4606158
Author(s) Wagner, Jonathan; Knaier, Raphael; Infanger, Denis; Königstein, Karsten; Klenk, Christopher; Carrard, Justin; Hanssen, Henner; Hinrichs, Timo; Seals, Douglas; Schmidt-Trucksäss, Arno
Author(s) at UniBasel Hinrichs, Timo
Carrard, Justin
Wagner, Jonathan
Year 2021
Title Novel CPET Reference Values in Healthy Adults: Associations with Physical Activity
Journal Medicine and Science in Sports and Exercise
Volume 53
Number 1
Pages / Article-Number 26-37
Mesh terms Adult; Aged; Aged, 80 and over; Cardiorespiratory Fitness; Exercise; Exercise Test, methods; Female; Humans; Male; Middle Aged; Prospective Studies; Reference Values; Young Adult
Abstract Cardiopulmonary exercise testing (CPET) is an important measurement in clinical practice and its primary outcome, maximal oxygen uptake (V[Combining Dot Above]O2peak), is inversely associated with morbidity and mortality. The purpose of this study is to provide CPET reference values for maximal and submaximal parameters across the adult age spectrum of a healthy European cohort, to compare V[Combining Dot Above]O2peak values with other reference datasets and to analyze the associations between physical activity (PA) levels and CPET parameters.; In this cross-sectional study, we prospectively recruited 502 participants (47% female) from 20 to 90 years old. The subjects performed a CPET on a cycle ergometer using a ramp protocol. PA was objectively and continuously measured over 14 days using a triaxial accelerometer. Quantile curves were calculated for CPET parameters. To investigate the associations between CPET parameters and PA levels, linear regression analysis was performed.; V[Combining Dot Above]O2peak values observed in the group of 20-29 years were 46.6±7.9 and 39.3±6.5 (mL/kg/min) for males and females, respectively. On average, each age category (10-year increments) showed a 10% lower V[Combining Dot Above]O2peak relative to the next younger age category. V[Combining Dot Above]O2peak values of previous studies were, on average 7.5 (mL/kg/min) (20%) lower for males and 6.5 (mL/kg/min) (21%) lower for females. There was strong evidence supporting a positive association between V[Combining Dot Above]O2peak (mL/kg/min) and the level of habitual PA performed at vigorous PA (estimate 0.26; p < 0.001].; Maximal and submaximal CPET reference values over a large age range are novel and differences to other studies are clinically highly relevant. Objectively measured vigorous-intensity PA showed a strong positive association with higher V[Combining Dot Above]O2peak and other performance-related CPET parameters, supporting the implementation of higher intensity aerobic exercise in health promotion.
Publisher Lippincott, Williams & Wilkins
ISSN/ISBN 0195-9131 ; 1530-0315
Full Text on edoc No
Digital Object Identifier DOI 10.1249/MSS.0000000000002454
PubMed ID
ISI-Number WOS:000598627800004
Document type (ISI) Journal Article

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