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A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4604870
Author(s) Joss, Daniel; Winter, Florine; Häussinger, Daniel
Author(s) at UniBasel Joss, Daniel
Winter, Florine
Häussinger, Daniel
Year 2020
Title A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR
Journal Chemical Communications
Volume 56
Number 84
Pages / Article-Number 12673-12870
Abstract Herein, a novel and rationally designed ortho-substituted pyridine activator is reported that reacts rapidly and selectively with cysteine thiols. It forms reduction-stable conjugates and induces large pseudocontact shifts, residual dipolar couplings and paramagnetic relaxation enhancement on both ubiquitin S57C and human carbonic anhydrase II S50C constructs under physiological conditions.
Publisher Royal Society of Chemistry
ISSN/ISBN 1359-7345 ; 1364-548X
edoc-URL https://edoc.unibas.ch/78803/
Full Text on edoc Available
Digital Object Identifier DOI 10.1039/d0cc04337k
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/32969418
 
   

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