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An adherence-enhancing program increases retention in care in the Swiss HIV Cohort
Journal
Open forum infectious diseases
Volume
7
Number
9
Pages / Article-Number
ofaa323
Keywords
HIV; adherence intervention; antiretrovirals; interprofessionality; medication retention in care
Abstract
This study tested a theory-based adherence-enhancing intervention: the "Interprofessional Medication Adherence Program" (IMAP) to increase human immunodeficiency virus (HIV) retention in care.; We retrospectively compared our intervention center (intervention group [IG]) with a standard of care center (control group [CG]) both participating in the Swiss HIV Cohort Study between 2004 and 2012. Endpoints were defined as >6-month and >12-month gaps in care for intervals of care longer than 6 and 12 months without any blood draw. Inverse probability of treatment weights was used to adjust for differences between patients at the 2 centers. Viral failure was defined as ribonucleic acid ≥50 copies/mL after 24+ weeks on antiretrovirals.; The IG included 451 patients, CG 311. In the IG, 179 (40%) patients took part in the IMAP for a median of 27 months (interquartile range, 12-45). Gaps in care of ≥6 months were significantly more likely to happen in the CG versus IG (74.6% vs 57%,; P; < .001). The median time until the first treatment gap was longer in the IG vs CG (120 vs 84 weeks,; P; < .001). Gaps in care of ≥12 months evaluated in 709 (93%) patients were significantly more likely to occur in the CG compared with the IG (22.6% vs 12.5%,; P; < .001). The rate of viral failure was significantly lower in the IG (8.3% vs 15.1%,; P; = .003).; This study, in a real-world setting, shows the effectiveness of the IMAP to reduce 6- and 12-month gaps in follow up among people with HIV. These results should be confirmed by studies in other settings.
