Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy - Modulators of Cellular Entry or Pharmacokinetics?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4601494
Author(s) Brecht, Karin; Schäfer, Anima Magdalena; Meyer zu Schwabedissen, Henriette E.
Author(s) at UniBasel Brecht Brüngger, Karin
Meyer zu Schwabedissen, Henriette
Schäfer, Anima Magdalena
Year 2020
Title Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy - Modulators of Cellular Entry or Pharmacokinetics?
Journal Cancers
Volume 12
Number 8
Pages / Article-Number 2263-2294
Keywords solute carrier transporters; genetic variants; cancer; chemotherapy; tumor
Abstract

Solute carrier transporters comprise a large family of uptake transporters involved in the transmembrane transport of a wide array of endogenous substrates such as hormones, nutrients, and metabolites as well as of clinically important drugs. Several cancer therapeutics, ranging from chemotherapeutics such as topoisomerase inhibitors, DNA-intercalating drugs, and microtubule binders to targeted therapeutics such as tyrosine kinase inhibitors are substrates of solute carrier (SLC) transporters. Given that SLC transporters are expressed both in organs pivotal to drug absorption,
distribution, metabolism, and elimination and in tumors, these transporters constitute determinants of cellular drug accumulation influencing intracellular drug concentration required for efficacy of the cancer treatment in tumor cells. In this review, we explore the current understanding of members of three SLC families, namely SLC21 (organic anion transporting polypeptides, OATPs), SLC22A (organic cation transporters, OCTs; organic cation/carnitine transporters, OCTNs; and organic anion transporters OATs), and SLC15A (peptide transporters, PEPTs) in the etiology of cancer, in transport of chemotherapeutic drugs, and their influence on ecacy or toxicity of pharmacotherapy. We further explore the idea to exploit the function of SLC transporters to enhance cancer cell accumulation of chemotherapeutics, which would be expected to reduce toxic side e ects in healthy tissue and to improve efficacy.

Publisher mdpi
URL https://www.mdpi.com/journal/cancers/special_issues/MRP
Full Text on edoc
Digital Object Identifier DOI doi:10.3390/cancers12082263
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/32806706
   

MCSS v5.8 PRO. 0.437 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
24/02/2024