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SPHN - The Swiss Aging Citizen Reference (SACR)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4599665
Author(s) Jeong, Ayoung; Bochud, Murielle; Cattin, Philippe; Dermitzakis, Manolis; Draganski, Bogdan; Papassotiropoulos, Andreas; Preisig, Martine; Stieltjes, Bram; Vollenweider, Peter; Probst-Hensch, Nicole
Author(s) at UniBasel Jeong, Ayoung
Probst Hensch, Nicole
Papassotiropoulos, Andreas
Year 2020
Title SPHN - The Swiss Aging Citizen Reference (SACR)
Journal Studies in health technology and informatics
Volume 270
Pages / Article-Number 1168-1169
Keywords DNA methylation; SPHN; aging; brain imaging; citizen reference; personalized health
Mesh terms Aging; Biomarkers; DNA Methylation; Humans; Magnetic Resonance Imaging; Reference Standards; Switzerland
Abstract In Switzerland by 2045, we expect 2.7 Mio citizens aged 65+ of whom 1.0 Mio. aged 80+. A priority and focus of personalized health research is therefore aging biology to extend healthy life expectancy. Novel molecular and imaging features will emerge as candidate targets for risk prediction and screening of chronic diseases. It is of utmost importance to test the clinical and public health utility of candidate biomarkers evolving from this research in citizen reference cohorts. We will build a Swiss Aging Citizen Reference (SACR), a testable and scalable reference cohort offering interoperable, searchable, and accessible data. 1000 participants from existing Swiss citizen cohorts will be combined and analyzed for DNA methylation and MRI brain imaging. SACR will serve as a testbed for clinical and public health utility of candidate biomarkers. As for a proof-of-concept study, we will conduct an agnostic search for structural and functional brain features associated with epigenetic aging acceleration to examine the potential of epigenetic age acceleration as the intermediate aging biomarker and to better understand the aging mechanism in brain.
Publisher IOS Press
ISSN/ISBN 0926-9630
Full Text on edoc Available
Digital Object Identifier DOI 10.3233/SHTI200347
PubMed ID
ISI-Number MEDLINE:32570565
Document type (ISI) Journal Article

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