Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4598457
Author(s) Eze, Ikenna C.; Jeong, Ayoung; Schaffner, Emmanuel; Rezwan, Faisal I.; Ghantous, Akram; Foraster, Maria; Vienneau, Danielle; Kronenberg, Florian; Herceg, Zdenko; Vineis, Paolo; Brink, Mark; Wunderli, Jean-Marc; Schindler, Christian; Cajochen, Christian; Röösli, Martin; Holloway, John W.; Imboden, Medea; Probst-Hensch, Nicole
Author(s) at UniBasel Eze, Ikenna
Jeong, Ayoung
Schaffner, Emmanuel
Foraster Pulido, Maria
Vienneau, Danielle
Schindler, Christian
Röösli, Martin
Imboden, Medea
Probst Hensch, Nicole
Year 2020
Title Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study
Journal Environmental Health Perspectives
Volume 128
Number 6
Pages / Article-Number 67003
Abstract Few epigenome-wide association studies (EWAS) on air pollutants exist, and none have been done on transportation noise exposures, which also contribute to environmental burden of disease.; We performed mutually independent EWAS on transportation noise and air pollution exposures.; We used data from two time points of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) from 1,389 participants contributing 2,542 observations. We applied multiexposure linear mixed-effects regressions with participant-level random intercept to identify significant Cytosine-phosphate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to 1-y average aircraft, railway, and road traffic day-evening-night noise (Lden); nitrogen dioxide (; NO; 2; ); and particulate matter (PM) with aerodynamic diameter; <; 2.5; μ; m; (; PM; 2.5; ). We performed candidate (CpG-based; cross-systemic phenotypes, combined into "allostatic load") and agnostic (DMR-based) pathway enrichment tests, and replicated previously reported air pollution EWAS signals.; We found no statistically significant CpGs at false discovery rate; <; 0.05; . However, 14, 48, 183, 8, and 71 DMRs independently associated with aircraft, railway, and road traffic Lden;; NO; 2; ; and; PM; 2.5; , respectively, with minimally overlapping signals. Transportation Lden and air pollutants tendentially associated with decreased and increased methylation, respectively. We observed significant enrichment of candidate DNA methylation related to C-reactive protein and body mass index (aircraft, road traffic Lden, and; PM; 2.5; ), renal function and "allostatic load" (all exposures). Agnostic functional networks related to cellular immunity, gene expression, cell growth/proliferation, cardiovascular, auditory, embryonic, and neurological systems development were enriched. We replicated increased methylation in cg08500171 (; NO; 2; ) and decreased methylation in cg17629796 (; PM; 2.5; ).; Mutually independent DNA methylation was associated with source-specific transportation noise and air pollution exposures, with distinct and shared enrichments for pathways related to inflammation, cellular development, and immune responses. These findings contribute in clarifying the pathways linking these exposures and age-related diseases but need further confirmation in the context of mediation analyses.
Publisher National Institute of Environmental Health Sciences
ISSN/ISBN 0091-6765 ; 1552-9924
Full Text on edoc No
Digital Object Identifier DOI 10.1289/EHP6174
PubMed ID
ISI-Number MEDLINE:32484729
Document type (ISI) Journal Article

MCSS v5.8 PRO. 0.336 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |