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Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4596447
Author(s) Burte, Emilie; Leynaert, Bénédicte; Marcon, Alessandro; Bousquet, Jean; Benmerad, Meriem; Bono, Roberto; Carsin, Anne-Elie; de Hoogh, Kees; Forsberg, Bertil; Gormand, Frederic; Heinrich, Joachim; Just, Jocelyne; Nieuwenhuijsen, Mark; Pin, Isabelle; Stempfelet, Morgane; Sunyer, Jordi; Villani, Simona; Künzli, Nino; Siroux, Valérie; Jarvis, Deborah; Nadif, Rachel; Jacquemin, Bénédicte
Author(s) at UniBasel de Hoogh, Kees
Künzli, Nino
Year 2020
Title Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts
Journal Journal of allergy and clinical immunology
Volume 145
Number 3
Pages / Article-Number 834-842.e6
Keywords Rhinitis; air pollution; allergic sensitization; environment; respiratory disease; severity
Abstract Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults.; We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis.; Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO; 2; , PM; 10; , PM; 2.5; , and PM; coarse; (calculated by subtracting PM; 2.5; from PM; 10; ) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used.; A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd quartile) score of rhinitis severity was 4 (2-6). Higher exposure to PM; 10; was associated with higher rhinitis severity (adjusted odds ratio [95% CI] for a 10 μg/m; 3; increase in PM; 10; : for mild: 1.20 [0.88-1.64], moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM; 2.5; . Higher exposure to NO; 2; was associated with an increased severity of rhinitis, with similar adjusted odds ratios whatever the level of severity. Adjusted odds ratios were higher among participants without allergic sensitization than among those with, but interaction was found only for NO; 2.; CONCLUSIONS: People with rhinitis who live in areas with higher levels of pollution are more likely to report more severe nasal symptoms. Further work is required to elucidate the mechanisms of this association.
Publisher Mosby
ISSN/ISBN 0091-6749
edoc-URL https://edoc.unibas.ch/76134/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jaci.2019.11.040
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/31983528
ISI-Number MEDLINE:31983528
Document type (ISI) Journal Article
 
   

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