New developments in phase refinement

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New developments in phase refinement

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4530925
Author(s)	Abrahams, J. P.; De Graaff, R. A. G.
Author(s) at UniBasel	Abrahams, Jan Pieter
Year	1998
Title	New developments in phase refinement
Journal	Current Opinion in Structural Biology
Volume	8
Number	5
Pages / Article-Number	601-5
Mesh terms	Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyCell BiologyBiochemistry & Molecular BiologyCell Biology
Abstract	A longstanding problem in X-ray crystallography is that vital information regarding the crystal phases is missing from the experimental data that are gathered in the diffraction experiment. Prior knowledge needs to be introduced in order to resolve phase ambiguities whenever the diffraction data are not sufficient to unequivocally reconstruct the crystal phases through anomalous or isomorphous differences. Very recent developments include progress in the application of direct methods to small proteins and other compounds of a similar small size (Shake 'n' Bake, SHELXD, CRUNCH and SIR96), bias-free refinement through the gamma-correction (Solomon), improvements in the determination of phase probability distributions (SHARP) and automated atomic refinement (wARP).
Publisher	Elsevier
ISSN/ISBN	0959-440X ; 1879-033X
edoc-URL	https://edoc.unibas.ch/75878/
Full Text on edoc	No
Digital Object Identifier DOI	10.1016/S0959-440X(98)80151-6
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/9818264
ISI-Number	000076586300010
Document type (ISI)	Journal Article, Review

15/05/2024

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