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Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4530905
Author(s) Accordini, Simone; Calciano, Lucia; Marcon, Alessandro; Pesce, Giancarlo; Antů, Josep M.; Beckmeyer-Borowko, Anna B.; Carsin, Anne-Elie; Corsico, Angelo G.; Imboden, Medea; Janson, Christer; Keidel, Dirk; Locatelli, Francesca; Svanes, Cecilie; Burney, Peter G. J.; Jarvis, Deborah; Probst-Hensch, Nicole M.; Minelli, Cosetta
Author(s) at UniBasel Beckmeyer-Borowko, Anna
Imboden, Medea
Probst Hensch, Nicole
Year 2020
Title Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
Journal Scientific reports
Volume 10
Number 1
Pages / Article-Number 3452
Abstract Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AO; post-BD; ), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AO; post-BD; was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AO; post-BD; incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AO; post-BD; incidence is expected to be half of AO incidence.
Publisher Springer Nature
ISSN/ISBN 0169-5487
edoc-URL https://edoc.unibas.ch/75867/
Full Text on edoc Available
Digital Object Identifier DOI 10.1038/s41598-020-60478-5
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/32103063
ISI-Number MEDLINE:32103063
Document type (ISI) Journal Article
 
   

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