Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Short term seasonal effects of airborne fungal spores on lung function in a panel study of schoolchildren residing in informal settlements of the Western Cape of South Africa
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4529790
Author(s) Olaniyan, Toyib; Dalvie, Mohamed Aqiel; Röösli, Martin; Naidoo, Rajen N.; Künzli, Nino; de Hoogh, Kees; Berman, Dilys; Parker, Bhawoodien; Leaner, Joy; Jeebhay, Mohamed F.
Author(s) at UniBasel Röösli, Martin
Künzli, Nino
de Hoogh, Kees
Year 2020
Title Short term seasonal effects of airborne fungal spores on lung function in a panel study of schoolchildren residing in informal settlements of the Western Cape of South Africa
Journal Environmental Pollution
Volume 260
Pages / Article-Number 114023
Keywords Children; Fungal spores; Lung function; Particulate matter; South Africa
Abstract The individual effects of biological constituents of particulate matter (PM) such as fungal spores, on lung function in children are not well known. This study investigated the seasonal short-term effect of daily variation in Alternaria and Cladosporium fungal spores on lung function in schoolchildren.; This panel study evaluated 313 schoolchildren in informal settlements of the Western Cape of South Africa, exposed to spores of two commonly encountered fungi, Alternaria and Cladosporium species. The children provided forced-expiratory volume in 1-s (FEV; 1; ) and peak-expiratory flow (PEF) measurements thrice daily for two consecutive school-weeks in summer and winter. Daily PM; 10; levels, from a stationary ambient air quality monitor and fungal spore levels using spore traps were measured in each study area throughout the year. The effects of Alternaria and Cladosporium spores, on lung function were analysed for lag periods up to five-days, adjusting-for PM; 10; , other pollen exposures, study area, and other host and meteorological factors. Same-day exposure-response curves were computed for both fungal species.; There was more variability in Alternaria spores level with noticeable peaks in summer. There were consistent lag-effects for Alternaria on PEF compared to Cladosporium, with the largest PEF deficit observed in winter (mean deficit: 13.78 L/min, 95%CI: 24.34 to -3.23 L/min) per 10spores/m; 3; increase in Alternaria spores on lag day-2. Although there were no observable lag-effects for Alternaria and Cladosporium on FEV; 1; , same-day effects of Cladosporium spores on FEV; 1; was present across both seasons. Threshold effects of Alternaria on both PEF and FEV; 1; deficits were apparent at levels of 100 spores/m; 3; , but could not be explored for Cladosporium beyond the levels observed during the study.; The study provides evidence for the independent effects of daily exposure to ambient fungal spores of Alternaria and Cladosporium on lung function deficits, more especially in winter for PEF.
Publisher Elsevier
ISSN/ISBN 0269-7491 ; 1873-6424
edoc-URL https://edoc.unibas.ch/75602/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.envpol.2020.114023
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/32018199
ISI-Number MEDLINE:32018199
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.329 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
14/06/2024