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A General Protocol for Robust Sonogashira Reactions in Micellar Medium
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4525042
Author(s) Jakobi, Markus; Gallou, Fabrice; Sparr, Christof; Parmentier, Michael
Author(s) at UniBasel Sparr, Christof
Jakobi, Markus
Year 2019
Title A General Protocol for Robust Sonogashira Reactions in Micellar Medium
Journal Helvetica Chimica Acta
Volume 102
Number 3
Pages / Article-Number e1900024
Abstract A robust and general protocol for a sustainable copper‐free Sonogashira cross coupling under micellar aqueous reaction conditions with high turnover was developed. By using the commercially available catalyst CataCXium A Pd G3 and THF as co‐solvent, various alkyne substrates were efficiently cross‐coupled with a broad range of aryl halides, providing improved yields and low catalyst loadings. The reaction parameters were optimized to render the process operationally simple, robust and scalable. The method gives access to alkynylated arenes, heterocyclic compounds, and monofunctionalized products from dihalogenated substrates with an improved selectivity achieved by the micellar aqueous reaction conditions.
Publisher Wiley
ISSN/ISBN 0018-019X ; 1522-2675
edoc-URL https://edoc.unibas.ch/74204/
Full Text on edoc Available
Digital Object Identifier DOI 10.1002/hlca.201900024
ISI-Number 000462096100012
Document type (ISI) Article
 
   

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