Common brain disorders are associated with heritable patterns of apparent aging of the brain
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4523519
Author(s)
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina J.; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine L.; Buitelaar, Jan; Celius, Elisabeth G.; Cervenka, Simon; Conzelmann, Annette; Córdova-Palomera, Aldo; Dale, Anders M.; de Quervain, Dominique J. F.; Di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend S.; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta K.; Harbo, Hanne F.; Hartman, Catharina A.; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar A.; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik G.; Karolinska Schizophrenia Project,; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut K.; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri J.; Maglanoc, Luigi A.; Malt, Ulrik F.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn B.; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav B.; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar M.; Tsolaki, Magda; Ulrichsen, Kristine M.; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole A.; Westlye, Lars T.
Author(s) at UniBasel
Papassotiropoulos, Andreas de Quervain, Dominique
Year
2019
Title
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Journal
Nature Neuroscience
Volume
22
Number
10
Pages / Article-Number
1617-1623
Mesh terms
Adolescent; Adult; Aged; Aged, 80 and over; Aging, genetics, pathology; Algorithms; Brain, diagnostic imaging, growth & development; Brain Diseases, diagnostic imaging, genetics; Child; Child, Preschool; Female; Genome-Wide Association Study; Humans; Infant; Magnetic Resonance Imaging; Male; Mental Disorders, diagnostic imaging, genetics; Middle Aged; Neuropsychological Tests; Schizophrenia, genetics, pathology; Sex Characteristics; Young Adult
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Publisher
Nature America
ISSN/ISBN
1097-6256 ; 1546-1726
URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823048/
edoc-URL
https://edoc.unibas.ch/73740/
Full Text on edoc
No
Digital Object Identifier DOI
10.1038/s41593-019-0471-7
PubMed ID
http://www.ncbi.nlm.nih.gov/pubmed/31551603
ISI-Number
WOS:000493396200012
Document type (ISI)
Journal Article
