A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4519719
Author(s) Moon, Ho-Sang; Jacobson, Eric M; Khersonsky, Sonya M; Luzung, Michael R; Walsh, Daniel P; Xiong, Wennan; Lee, Jae Wook; Parikh, Puja B; Lam, Jennifer C; Kang, Tae-Wook; Rosania, Gustavo R; Schier, Alexander F; Chang, Young-Tae
Author(s) at UniBasel Schier, Alexander
Year 2002
Title A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
Journal Journal of the American Chemical Society
Volume 124
Number 39
Pages / Article-Number 11608-9
Mesh terms Animals; Antineoplastic Agents, chemical synthesis, chemistry, pharmacology; Drug Screening Assays, Antitumor, methods; Microtubules, drug effects; Purines, chemistry, pharmacology; Structure-Activity Relationship; Triazines, chemical synthesis, chemistry, pharmacology; Zebrafish, embryology
Abstract

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

ISSN/ISBN 0002-7863
URL https://pubs.acs.org/doi/10.1021/ja026720i
Full Text on edoc
Digital Object Identifier DOI 10.1021/ja026720i
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/12296721
   

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