Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4519719
Author(s)
Moon, Ho-Sang; Jacobson, Eric M.; Khersonsky, Sonya M.; Luzung, Michael R.; Walsh, Daniel P.; Xiong, Wennan; Lee, Jae Wook; Parikh, Puja B.; Lam, Jennifer C.; Kang, Tae-Wook; Rosania, Gustavo R.; Schier, Alexander F.; Chang, Young-Tae
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening
Journal
Journal of the American Chemical Society
Volume
124
Number
39
Pages / Article-Number
11608-11609
Mesh terms
Animals; Antineoplastic Agents, chemical synthesis, chemistry, pharmacology; Drug Screening Assays, Antitumor, methods; Microtubules, drug effects; Purines, chemistry, pharmacology; Structure-Activity Relationship; Triazines, chemical synthesis, chemistry, pharmacology; Zebrafish, embryology
Abstract
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.