A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4519719
Author(s) Moon, Ho-Sang; Jacobson, Eric M.; Khersonsky, Sonya M.; Luzung, Michael R.; Walsh, Daniel P.; Xiong, Wennan; Lee, Jae Wook; Parikh, Puja B.; Lam, Jennifer C.; Kang, Tae-Wook; Rosania, Gustavo R.; Schier, Alexander F.; Chang, Young-Tae
Author(s) at UniBasel Schier, Alexander
Year 2002
Title A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening
Journal Journal of the American Chemical Society
Volume 124
Number 39
Pages / Article-Number 11608-11609
Mesh terms Animals; Antineoplastic Agents, chemical synthesis, chemistry, pharmacology; Drug Screening Assays, Antitumor, methods; Microtubules, drug effects; Purines, chemistry, pharmacology; Structure-Activity Relationship; Triazines, chemical synthesis, chemistry, pharmacology; Zebrafish, embryology
Abstract The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
Publisher American Chemical Society
ISSN/ISBN 0002-7863 ; 1520-5126
edoc-URL https://edoc.unibas.ch/74889/
Full Text on edoc No
Digital Object Identifier DOI 10.1021/ja026720i
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/12296721
ISI-Number WOS:000178317100024
Document type (ISI) Article
 
   

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