Assembly of trigeminal sensory ganglia by chemokine signaling.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4519698
Author(s) Knaut, Holger; Blader, Patrick; Strähle, Uwe; Schier, Alexander F
Author(s) at UniBasel Schier, Alexander
Year 2005
Title Assembly of trigeminal sensory ganglia by chemokine signaling.
Journal Neuron
Volume 47
Number 5
Pages / Article-Number 653-66
Mesh terms Animals; Cadherins, physiology; Chemokine CXCL12; Chemokines, physiology; Chemokines, CXC, biosynthesis, genetics; Ganglia, Sensory, cytology, physiology; In Situ Hybridization; Morpholines, pharmacology; Neurons, physiology; Neurons, Afferent, physiology; Receptors, CXCR4, physiology; Signal Transduction, physiology; Trigeminal Ganglion, cytology, physiology; Zebrafish
Abstract

Sensory neurons with related functions form ganglia, but how these precisely positioned clusters are assembled has been unclear. Here, we use the zebrafish trigeminal sensory ganglion as a model to address this question. We find that some trigeminal sensory neurons are born at the position where the ganglion is assembled, whereas others are born at a distance and have to migrate against opposing morphogenetic movements to reach the site of ganglion assembly. Loss of Cxcr4b-mediated chemokine signaling results in the formation of mispositioned ganglia. Conversely, ectopic sources of the chemokine SDF1a can attract sensory neurons. Transplantation experiments reveal that neuron-neuron interaction and the adhesion molecules E- and N-Cadherin also contribute to ganglion assembly. These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion.

ISSN/ISBN 0896-6273
URL https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(05)00608-2
Full Text on edoc
Digital Object Identifier DOI 10.1016/j.neuron.2005.07.014
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/16129396
   

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