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Functional aging in health and heart failure: the COmPLETE Study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4515766
Author(s) Wagner, Jonathan; Knaier, Raphael; Infanger, Denis; Arbeev, Konstantin; Briel, Matthias; Dieterle, Thomas; Hanssen, Henner; Faude, Oliver; Roth, Ralf; Hinrichs, Timo; Schmidt-Trucksäss, Arno
Author(s) at UniBasel Hinrichs, Timo
Knaier, Raphael
Wagner, Jonathan
Year 2019
Title Functional aging in health and heart failure: the COmPLETE Study
Journal BMC Cardiovascular Disorders
Volume 19
Number 1
Pages / Article-Number 180
Keywords Aging; Exercise; Fitness; Heart failure; Vascular function
Mesh terms Adult; Age Factors; Aged; Aged, 80 and over; Cardiorespiratory Fitness; Cross-Sectional Studies; Female; Geriatric Assessment; Healthy Aging; Heart Failure, physiopathology; Humans; Male; Middle Aged; Prognosis; Protective Factors; Research Design; Risk Assessment; Risk Factors; Switzerland, epidemiology; Young Adult
Abstract Cardiovascular (CV) diseases including heart failure are the leading causes of morbidity, with age being the primary risk factor. The combination of age-related organic functional impairment and reduced physical fitness can drastically impact an individual's healthspan. One's lifespan can potentially be prolonged by the preservation or improvement of physical fitness. However, it remains unclear as to which biomarkers are most suitable for distinguishing between healthy aging and the impaired organ function associated with heart failure. Therefore, a comprehensive assessment of the components of physical fitness and CV function will be performed to identify the most important factors contributing to aging in relation to both health and disease.; This cross-sectional investigation will consist of two parts: COmPLETE-Health (C-Health) and COmPLETE-Heart (C-Heart). C-Health will examine the aging trajectories of physical fitness components and CV properties in a healthy population sample aged between 20 and 100 years (n = 490). Separately, C-Heart will assess the same markers in patients at different stages of chronic heart failure (n = 80). The primary outcome to determine the difference between C-Health and C-Heart will be cardiorespiratory fitness as measured by cardiopulmonary exercise testing on a bicycle ergometer. Secondary outcomes will include walking speed, balance, isometric strength, peak power, and handgrip strength. Physical activity as a behavioural component will be assessed objectively via accelerometry. Further, CV assessments will include pulse wave velocity; retinal, arterial, and venous diameters; brachial and retinal arterial endothelial function; carotid intima-media thickness; and systolic and diastolic function. The health distances for C-Health and C-Heart will be calculated using the methodology based on statistical (Mahalanobis) distance applied to measurements of quantitative biomarkers.; This research seeks to identify physical fitness and CV biomarkers that best resemble underlying CV risk with age. Further, it will examine which physical fitness markers are impaired most in heart failure. The presented integrative approach could define new recommendations for diagnostic guidance in aging. Ultimately, this study is expected to offer a better understanding of which functional characteristics should be specifically targeted in primary and secondary prevention to achieve an optimal healthspan.
Publisher BioMed Central
ISSN/ISBN 1471-2261
Full Text on edoc No
Digital Object Identifier DOI 10.1186/s12872-019-1164-6
PubMed ID
ISI-Number WOS:000477938800001
Document type (ISI) Journal Article

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