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Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4515186
Author(s) Wang, Jing; Brodmann, Maj; Basler, Marek
Author(s) at UniBasel Basler, Marek
Year 2019
Title Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems
Journal Annual Review of Microbiology
Volume 73
Pages / Article-Number 621-638
Keywords bacterial secretion systems; contractile nanomachines; sensing and signaling cascades; subcellular localization
Abstract Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even across membranes of neighboring cells to influence their environment, prevent predation, defeat competitors, or communicate. A variety of protein-secretion systems have evolved to make this process highly regulated and efficient. The type VI secretion system (T6SS) is one of the largest dynamic assemblies in gram-negative bacteria and allows for delivery of toxins into both bacterial and eukaryotic cells. The recent progress in structural biology and live-cell imaging shows the T6SS as a long contractile sheath assembled around a rigid tube with associated toxins anchored to a cell envelope by a baseplate and membrane complex. Rapid sheath contraction releases a large amount of energy used to push the tube and toxins through the membranes of neighboring target cells. Because reach of the T6SS is limited, some bacteria dynamically regulate its subcellular localization to precisely aim at their targets and thus increase efficiency of toxin translocation.
Publisher Annual Reviews
ISSN/ISBN 0066-4227 ; 1545-3251
URL https://www.annualreviews.org/doi/abs/10.1146/annurev-micro-020518-115420
edoc-URL https://edoc.unibas.ch/72345/
Full Text on edoc Available
Digital Object Identifier DOI 10.1146/annurev-micro-020518-115420
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/31226022
ISI-Number WOS:000485114700029
Document type (ISI) Journal Article
 
   

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