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Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients (MAAESTRO)
Project funded by own resources |
Project title |
Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients (MAAESTRO) |
Principal Investigator(s) |
Arnet, Isabelle Lyrer, Philippe A.
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Co-Investigator(s) |
Polymeris, Alexandros
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Project Members |
Albert, Valerie Dietrich, Fine Michèle
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Organisation / Research unit |
Departement Pharmazeutische Wissenschaften / Pharmaceutical Care (Allemann) |
Project start |
01.12.2017 |
Probable end |
31.12.2023 |
Status |
Active |
Abstract |
Primary objective of the MAAESTRO trial is to evaluate the impact of an educational and reminder-based intervention on the adherence of stroke patients to direct oral anticoagulants (DOACs). Secondary objectives are to evaluate the association between non-adherence and clinical events, to identify predictors of non-adherence and to compare objective measures of adherence with self-reporting.
Key methodological instrument for this study will be the electronic device "Time4Med" as Smart and Reminder Card affixed on a pillbox. The study includes 3 visits (baseline visit 0, follow-up visit 1, end-of-study visit 2) with a total follow-up of 12 months.
After an initial 6-month observational phase with electronic monitoring of adherence using the "Smart Card", all patients will receive counselling based on their electronically recorded drug intake data, as well as a multicompartment pillbox. Patients will be then randomised to one of two groups in a crossover design, so that in the subsequent 6-month interventional phase one group will use a (reminder-delivering) "Reminder Card" for the first 3 months and the "Smart Card" for the last 3 months, while the second group will use the cards in reverse order. |
Keywords |
ischemic stroke, direct oral anticoagulants, adherence, electronic monitoring, adherence-improving intervention, polypharmacy |
Financed by |
University funds Other funds
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Published results () |
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ID |
Autor(en) |
Titel |
ISSN / ISBN |
Erschienen in |
Art der Publikation |
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4526314 |
Polymeris, Alexandros A.; Albert, Valerie; Hersberger, Kurt E.; Engelter, Stefan T.; Schaedelin, Sabine; Arnet, Isabelle; Lyrer, Philippe A. |
Protocol for MAAESTRO: Electronic Monitoring and Improvement of Adherence to Direct Oral Anticoagulant Treatment-A Randomized Crossover Study of an Educational and Reminder-Based Intervention in Ischemic Stroke Patients Under Polypharmacy |
1664-2295 |
Frontiers in Neurology |
JournalItem (Kommentare, Editorials, Rezensionen, Urteilsanmerk., etc. in einer wissensch. Zeitschr. |
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29/11/2023
Research Database / FORSCHUNGSDATENBANK
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