Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients (MAAESTRO)
Project funded by own resources
Project title Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients (MAAESTRO)
Principal Investigator(s) Arnet, Isabelle
Lyrer, Philippe A.
Co-Investigator(s) Polymeris, Alexandros
Project Members Albert, Valerie
Dietrich, Fine Michèle
Organisation / Research unit Departement Pharmazeutische Wissenschaften / Pharmaceutical Care (Hersberger)
Project start 01.12.2017
Probable end 31.12.2021
Status Active
Abstract

Primary objective of the MAAESTRO trial is to evaluate the impact of an educational and reminder-based intervention on the adherence of stroke patients to direct oral anticoagulants (DOACs). Secondary objectives are to evaluate the association between non-adherence and clinical events, to identify predictors of non-adherence and to compare objective measures of adherence with self-reporting.

Key methodological instrument for this study will be the electronic device "Time4Med" as Smart and Reminder Card affixed on a pillbox. The study includes 3 visits (baseline visit 0, follow-up visit 1, end-of-study visit 2) with a total follow-up of 12 months.

After an initial 6-month observational phase with electronic monitoring of adherence using the "Smart Card", all patients will receive counselling based on their electronically recorded drug intake data, as well as a multicompartment pillbox. Patients will be then randomised to one of two groups in a crossover design, so that in the subsequent 6-month interventional phase one group will use a (reminder-delivering) "Reminder Card" for the first 3 months and the "Smart Card" for the last 3 months, while the second group will use the cards in reverse order.

Keywords ischemic stroke, direct oral anticoagulants, adherence, electronic monitoring, adherence-improving intervention, polypharmacy
Financed by University funds
Other funds

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
4526314  Polymeris, Alexandros A.; Albert, Valerie; Hersberger, Kurt E.; Engelter, Stefan T.; Schaedelin, Sabine; Arnet, Isabelle; Lyrer, Philippe A.  Protocol for MAAESTRO: Electronic Monitoring and Improvement of Adherence to Direct Oral Anticoagulant Treatment-A Randomized Crossover Study of an Educational and Reminder-Based Intervention in Ischemic Stroke Patients Under Polypharmacy  1664-2295  Frontiers in Neurology  JournalItem (Kommentare, Editorials, Rezensionen, Urteilsanmerk., etc. in einer wissensch. Zeitschr. 
   

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