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(+/-)-Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternata p1210 isolated from the halophyte Salicornia sp
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4513762
Author(s)
Shi, Yan-Ni; Pusch, Stefan; Shi, Yi-Ming; Richter, Christian; Maciá-Vicente, Jose G.; Schwalbe, Harald; Kaiser, Marcel; Opatz, Till; Bode, Helge B.
(+/-)-Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternata p1210 isolated from the halophyte Salicornia sp
Journal
Journal of Organic Chemistry
Volume
84
Number
17
Pages / Article-Number
11203-11209
Abstract
Two new dimeric compounds of the alternariol class, (±)-alternarlactones A (; 1; ) and B (; 2; ), were isolated along with 11 known compounds from the fungus; Alternaria alternata; P1210. Their structures were elucidated with the assistance of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense quaternary carbons, as well as theoretical calculations. All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases.
