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Air pollution, lung function and COPD : results from the population-based UK Biobank study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4511614
Author(s) Doiron, Dany; de Hoogh, Kees; Probst-Hensch, Nicole; Fortier, Isabel; Cai, Yutong; De Matteis, Sara; Hansell, Anna L.
Author(s) at UniBasel Doiron, Dany
de Hoogh, Kees
Probst Hensch, Nicole
Year 2019
Title Air pollution, lung function and COPD : results from the population-based UK Biobank study
Journal The European respiratory journal
Volume 54
Number 1
Pages / Article-Number 1802140
Abstract Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors.We used UK Biobank data on 303 887 individuals aged 40-69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 m: PM; 2.5; and PM; 10; , respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PM; coarse; ) and nitrogen dioxide (NO; 2; ) concentrations with forced expiratory volume in 1 s (FEV; 1; ), forced vital capacity (FVC), the FEV; 1; /FVC ratio and COPD (FEV; 1; /FVC <lower limit of normal). Effect modification was investigated for sex, age, obesity, smoking status, household income, asthma status and occupations previously linked to COPD.Higher exposures to each pollutant were significantly associated with lower lung function. A 5 gm; -3; increase in PM; 2.5; concentration was associated with lower FEV; 1; (-83.13 mL, 95% CI -92.50--73.75 mL) and FVC (-62.62 mL, 95% CI -73.91--51.32 mL). COPD prevalence was associated with higher concentrations of PM; 2.5; (OR 1.52, 95% CI 1.42-1.62, per 5 gm; -3; ), PM; 10; (OR 1.08, 95% CI 1.00-1.16, per 5 gm; -3; ) and NO; 2; (OR 1.12, 95% CI 1.10-1.14, per 10 gm; -3; ), but not with PM; coarse; Stronger lung function associations were seen for males, individuals from lower income households, and "at-risk" occupations, and higher COPD associations were seen for obese, lower income, and non-asthmatic participants.Ambient air pollution was associated with lower lung function and increased COPD prevalence in this large study.
Publisher Munksgaard
ISSN/ISBN 0903-1936
Full Text on edoc No
Digital Object Identifier DOI 10.1183/13993003.02140-2018
PubMed ID
Document type (ISI) Journal Article

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