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Definitions and guidelines for research on antibiotic persistence
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4511034
Author(s) Balaban, Nathalie Q.; Helaine, Sophie; Lewis, Kim; Ackermann, Martin; Aldridge, Bree; Andersson, Dan I.; Brynildsen, Mark P.; Bumann, Dirk; Camilli, Andrew; Collins, James J.; Dehio, Christoph; Fortune, Sarah M.; Ghigo, Jean-Marc; Hardt, Wolf-Dietrich; Harms, Alexander; Heinemann, Matthias; Hung, Deborah T.; Jenal, Urs; Levin, Bruce R.; Michiels, Jan; Storz, Gisela; Tan, Man-Wah; Tenson, Tanel; Van Melderen, Laurence; Zinkernagel, Annelies
Author(s) at UniBasel Harms, Alexander
Bumann, Dirk
Dehio, Christoph
Jenal, Urs
Year 2019
Title Definitions and guidelines for research on antibiotic persistence
Journal Nature Reviews Microbiology
Volume 17
Number 7
Pages / Article-Number 441-448
Mesh terms Anti-Bacterial Agents, pharmacology; Bacteria, drug effects; Biomedical Research, standards; Drug Tolerance; Guidelines as Topic; Terminology as Topic
Abstract Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
Publisher Nature Publishing Group
ISSN/ISBN 1740-1526 ; 1740-1534
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136161/
edoc-URL https://edoc.unibas.ch/71590/
Full Text on edoc No
Digital Object Identifier DOI 10.1038/s41579-019-0196-3
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/30980069
Document type (ISI) Journal Article, Review
 
   

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